Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jan 17

PMID 28091607

Citations 19

Authors

Norimasa Kikuchi

Takeshi Nishiyama

Takayuki Sawada

Chaochen Wang

Yingsong Lin

Yoshiyuki Watanabe

Akiko Tamakoshi

Shogo Kikuchi

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer is the third most common cancer worldwide, and many risk factors for colorectal cancer have been established. However, it remains uncertain whether psychological stress contributes to the onset of colorectal cancer. Therefore, we conducted a large-scale prospective cohort study to confirm the association between perceived stress and colorectal cancer incidence. We identified 680 cases of colon cancer and 330 cases of rectal cancer during a maximum of 21-year follow-up of 61,563 Japanese men and women. Cox regression analysis adjusted for potential confounders revealed a significant association of perceived stress with rectal cancer incidence but not with colon cancer incidence. This finding is partly consistent with that from only one previous study that addressed an association between perceived stress and the risk of colorectal cancer. However, studies on this topic are sparse and warrant further exploration.

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