Mechanochemical Functionalization of Disulfide Linked Hydrogels

Overview

Journal Mater Horiz

Publisher Royal Society of Chemistry

Specialty Biomedical Engineering

Date 2017 Jan 17

PMID 28090330

Citations 7

Authors

Junmin Lee

Meredith N Silberstein

Amr A Abdeen

Sang Yup Kim

Kristopher A Kilian

Affiliations

Soon will be listed here.

Abstract

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

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