A Common Variant in SCN5A and the Risk of Ventricular Fibrillation Caused by First ST-Segment Elevation Myocardial Infarction

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jan 14

PMID 28085969

Citations 12

Authors

Reza Jabbari

Charlotte Glinge

Javad Jabbari

Bjarke Risgaard

Bo Gregers Winkel

Christian Juhl Terkelsen

Hans-Henrik Tilsted

Lisette Okkels Jensen

Mikkel Hougaard

Stig Haunso

Thomas Engstrom

Christine M Albert

Jacob Tfelt-Hansen

Affiliations

Soon will be listed here.

Abstract

Background: Several common genetic variants have been associated with either ventricular fibrillation (VF) or sudden cardiac death (SCD). However, replication efforts have been limited. Therefore, we aimed to analyze whether such variants may contribute to VF caused by first ST-elevation myocardial infarction (STEMI).

Methods: We analyzed 27 single nucleotide polymorphisms (SNP) previously associated with SCD/VF in other cohorts, and examined whether these SNPs were associated with VF caused by first STEMI in the GEnetic causes of Ventricular Arrhythmias in patients with first ST-elevation Myocardial Infarction (GEVAMI) study on ethnical Danes. The GEVAMI study is a prospective case-control study involving 257 cases (STEMI with VF) and 537 controls (STEMI without VF).

Results: Of the 27 candidate SNPs, one SNP (rs11720524) located in intron 1 of SCN5A which was previously associated with SCD was significantly associated with VF caused by first STEMI. The major C-allele of rs11720524 was present in 64% of the cases and the C/C genotype was significantly associated with VF with an odds ratio (OR) of 1.87 (95% CI: 1.12-3.12; P = 0.017). After controlling for clinical differences between cases and controls such as age, sex, family history of sudden death, alcohol consumption, previous atrial fibrillation, statin use, angina, culprit artery, and thrombolysis in myocardial infarction (TIMI) flow, the C/C genotype of rs11720524 was still significantly associated with VF with an OR of 1.9 (95% CI: 1.05-3.43; P = 0.032). Marginal associations with VF were also found for rs9388451 in HEY2 gene. The CC genotype showed an insignificant risk for VF with OR = 1.50 (95% CI: 0.96-2.40; P = 0.070).

Conclusion: One common intronic variant in SCN5A suggested an association with VF caused by first STEMI. Further studies into the functional abnormalities associated with the noncoding variant in SCN5A may lead to important insights into predisposition to VF during STEMI.

Citing Articles

Ventricular arrhythmias during ST-segment elevation myocardial infarction and arrhythmic complications during recurrent ischaemic events.

Demidova M, Holmqvist F, Erlinge D, Platonov P Eur Heart J. 2023; 45(5):393-395.

PMID: 37935589 PMC: 10834155. DOI: 10.1093/eurheartj/ehad740.

Risk stratification of sudden cardiac death: a review.

Tfelt-Hansen J, Garcia R, Albert C, Merino J, Krahn A, Marijon E Europace. 2023; 25(8).

PMID: 37622576 PMC: 10450787. DOI: 10.1093/europace/euad203.

Incidence, Characteristics, and Outcomes of Ventricular Fibrillation Complicating Acute Myocardial Infarction in Women Admitted Alive in the Hospital.

Weizman O, Marijon E, Narayanan K, Boveda S, Defaye P, Martins R J Am Heart Assoc. 2022; 11(17):e025959.

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Identification of Cx43 variants predisposing to ventricular fibrillation in the acute phase of ST-elevation myocardial infarction.

Chevalier P, Moreau A, Bessiere F, Richard S, Chahine M, Millat G Europace. 2022; 25(1):101-111.

PMID: 35942675 PMC: 10103570. DOI: 10.1093/europace/euac128.

Circulating virome and inflammatory proteome in patients with ST-elevation myocardial infarction and primary ventricular fibrillation.

Oliveras T, Revuelta-Lopez E, Garcia-Garcia C, Cserkoova A, Rueda F, Labata C Sci Rep. 2022; 12(1):7910.

PMID: 35552514 PMC: 9098642. DOI: 10.1038/s41598-022-12075-x.

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