Gadolinium Deposition in the Brain: Association with Various GBCAs Using a Generalized Additive Model

Overview

Journal Eur Radiol

Specialty Radiology

Date 2017 Jan 14

PMID 28083696

Citations 16

Authors

Sohi Bae

Ho-Joon Lee

Kyunghwa Han

Yae-Won Park

Yoon Seong Choi

Sung Soo Ahn

Jinna Kim

Seung-Koo Lee

Affiliations

Soon will be listed here.

Abstract

Objectives: To determine the relationship between the number of administrations of various gadolinium-based contrast agents (GBCAs) and increased T1 signal intensity in the globus pallidus (GP) and dentate nucleus (DN).

Methods: This retrospective study included 122 patients who underwent double-dose GBCA-enhanced magnetic resonance imaging. Two radiologists calculated GP-to-thalamus (TH) signal intensity ratio, DN-to-pons signal intensity ratio and relative change (R) between the baseline and final examinations. Interobserver agreement was evaluated. The relationships between R and several factors, including number of each GBCA administrations, were analysed using a generalized additive model.

Results: Six patients (4.9%) received linear GBCAs (mean 20.8 number of administration; range 15-30), 44 patients (36.1%) received macrocyclic GBCAs (mean 26.1; range 14-51) and 72 patients (59.0%) received both types of GBCAs (mean 31.5; range 12-65). Interobserver agreement was almost perfect (0.99; 95% CI: 0.99-0.99). R (DN:pons) was associated with gadodiamide (p = 0.006) and gadopentetate dimeglumine (p < 0.001), but not with other GBCAs. R (GP:TH) was not associated with GBCA administration.

Conclusions: Previous administration of linear agents gadoiamide and gadopentetate dimeglumine is associated with increased T1 signal intensity in the DN, whereas macrocyclic GBCAs do not show an association.

Key Points: • Certain linear GBCAs are associated with T1 signal change in the dentate nucleus. • The signal change is related to the administration number of certain linear GBCAs. • Difference in signal change may reflect differences in stability of agents.

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