Comparative Genomics of and Non-Pylori Species to Identify New Regions Associated with Its Pathogenicity and Adaptability

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2017 Jan 13

PMID 28078297

Citations 11

Authors

De-Min Cao

Qun-Feng Lu

Song-Bo Li

Ju-Ping Wang

Yu-Li Chen

Yan-Qiang Huang

Hong-Kai Bi

Affiliations

Soon will be listed here.

Abstract

The genus is a group of Gram-negative, helical-shaped pathogens consisting of at least 36 bacterial species. (), infecting more than 50% of the human population, is considered as the major cause of gastritis, peptic ulcer, and gastric cancer. However, the genetic underpinnings of that are responsible for its large scale epidemic and gastrointestinal environment adaption within human beings remain unclear. Core-pan genome analysis was performed among 75 representative and 24 non- genomes. There were 1173 conserved protein families of and 673 of all 99 genus strains. We found 79 genome unique regions, a total of 202,359bp, shared by at least 80% of the but lacked in non- species. The operons, genes, and sRNAs within the unique regions were considered as potential ones associated with its pathogenicity and adaptability, and the relativity among them has been partially confirmed by functional annotation analysis. However, functions of at least 54 genes and 10 sRNAs were still unclear. Our analysis of protein-protein interaction showed that 30 genes within them may have the cooperation relationship.

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