Identification and Clinical Course of 166 Pediatric Cardiac Tumors

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2017 Jan 12

PMID 28074279

Citations 32

Authors

Lin Shi

Lanping Wu

Huijuan Fang

Bo Han

Jialun Yang

Xiaojin Ma

Fang Liu

Yongwei Zhang

Tingting Xiao

Min Huang

Meirong Huang

Affiliations

Soon will be listed here.

Abstract

Conclusion: The primary benign cardiac tumors are the predominant pediatric cardiac tumors, of which rhabdomyoma, fibroma, and myxoma are the most common types. If severe symptoms are nonexistent and the hemodynamics is unaffected, most of the patients can survive in the long term despite the tumors. What is known: • Pediatric cardiac tumors are rare and are predominantly primary and benign. • The symptoms of heart failure, arrhythmia, and outflow obstruction are the most severe complications of cardiac tumors. What is new: • The rhabdomyoma, fibroma, and myxoma are the most common types of primary benign cardiac tumors. • If severe symptoms are not present and the hemodynamics are unaffected, most of the patients can survive in the long term despite the tumors.

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References

Valente M, Cocco P, Thiene G, Casula R, Poletti A, Milanesi O . Cardiac fibroma and heart transplantation. J Thorac Cardiovasc Surg. 1993; 106(6):1208-12. View

Penha J, Zorzanelli L, Barbosa-Lopes A, Aiello V, Carvalho V, Caneo L . Heart neoplasms in children: retrospective analysis. Arq Bras Cardiol. 2013; 100(2):120-6. DOI: 10.5935/abc.20130024. View

Centofanti P, Di Rosa E, Deorsola L, Dato G, Patane F, La Torre M . Primary cardiac tumors: early and late results of surgical treatment in 91 patients. Ann Thorac Surg. 1999; 68(4):1236-41. DOI: 10.1016/s0003-4975(99)00700-6. View

Careddu L, Oppido G, Petridis F, Liberi R, Ragni L, Pacini D . Primary cardiac tumours in the paediatric population. Multimed Man Cardiothorac Surg. 2014; 2013:mmt013. DOI: 10.1093/mmcts/mmt013. View

Kimura N, Matsubara M, Atsumi N, Terada M . Successful surgical removal of a giant interventricular fibroma: surgical approach without ventriculotomy. Ann Thorac Surg. 2013; 95(3):1072-4. DOI: 10.1016/j.athoracsur.2012.08.028. View

Reber D, Birnbaum D . Recurrent cardiac myxoma: why it occurs. A case report with literature review. J Cardiovasc Surg (Torino). 2001; 42(3):345-8. View

Dogan V, Yesil S, Kayali S, Beken S, Ozgur S, Ertugrul I . Regression of symptomatic multiple cardiac rhabdomyomas associated with tuberous sclerosis complex in a newborn receiving everolimus. J Trop Pediatr. 2014; 61(1):74-7. DOI: 10.1093/tropej/fmu056. View

Strecker T, Agaimy A, Marwan M, Zielezinski T . Papillary fibroelastoma of the aortic valve: appearance in echocardiography, computed tomography, and histopathology. J Heart Valve Dis. 2011; 19(6):812. View

Liu X . [Tuberous sclerosis complex and cardiac rhabdomyoma]. Zhonghua Er Ke Za Zhi. 2014; 52(3):234-7. View

10.

Kamiya H, Yasuda T, Nagamine H, Sakakibara N, Nishida S, Kawasuji M . Surgical treatment of primary cardiac tumors: 28 years' experience in Kanazawa University Hospital. Jpn Circ J. 2001; 65(4):315-9. DOI: 10.1253/jcj.65.315. View

11.

Jozwiak S, Kotulska K, Kasprzyk-Obara J, Domanska-Pakiela D, Tomyn-Drabik M, Roberts P . Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex. Pediatrics. 2006; 118(4):e1146-51. DOI: 10.1542/peds.2006-0504. View

12.

Cina S, Smialek J, Burke A, Virmani R, Hutchins G . Primary cardiac tumors causing sudden death: a review of the literature. Am J Forensic Med Pathol. 1996; 17(4):271-81. DOI: 10.1097/00000433-199612000-00001. View

13.

Huh J, Noh C, Kim Y, Choi J, Yun Y, Shin H . Secondary cardiac tumor in children. Pediatr Cardiol. 1999; 20(6):400-3. DOI: 10.1007/s002469900500. View

14.

Miyake C, Del Nido P, Alexander M, Cecchin F, Berul C, Triedman J . Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia. J Am Coll Cardiol. 2011; 58(18):1903-9. DOI: 10.1016/j.jacc.2011.08.005. View

15.

Kitzing B . Cardiac lipoma in a patient with a history of malignant tumours: a case report. Cases J. 2008; 1(1):41. PMC: 2483951. DOI: 10.1186/1757-1626-1-41. View

16.

Iida Y, Ito T, Kitahara H, Takebe M, Nemoto A, Shimokawa R . Successful detection and surgical treatment of cardiac hemangioma with right ventricular invasion. Ann Thorac Surg. 2013; 96(4):1481-1483. DOI: 10.1016/j.athoracsur.2013.02.054. View

17.

Roberts W . Primary and secondary neoplasms of the heart. Am J Cardiol. 1997; 80(5):671-82. DOI: 10.1016/s0002-9149(97)00587-0. View

18.

Jha N, Khouri M, Murphy D, Salustri A, Khan J, Saleh M . Papillary fibroelastoma of the aortic valve--a case report and literature review. J Cardiothorac Surg. 2010; 5:84. PMC: 2965711. DOI: 10.1186/1749-8090-5-84. View

19.

Burke A, Virmani R . Pediatric heart tumors. Cardiovasc Pathol. 2008; 17(4):193-8. DOI: 10.1016/j.carpath.2007.08.008. View

20.

Burke A, Johns J, Virmani R . Hemangiomas of the heart. A clinicopathologic study of ten cases. Am J Cardiovasc Pathol. 1990; 3(4):283-90. View