Embryonic Origin of Adult Stem Cells Required for Tissue Homeostasis and Regeneration

Overview

Journal Elife

Specialty Biology

Date 2017 Jan 11

PMID 28072387

Citations 40

Authors

Erin L Davies

Kai Lei

Christopher W Seidel

Amanda E Kroesen

Sean A McKinney

Longhua Guo

Sofia Mc Robb

Eric J Ross

Kirsten Gotting

Alejandro Sanchez Alvarado

Affiliations

Soon will be listed here.

Abstract

Planarian neoblasts are pluripotent, adult somatic stem cells and lineage-primed progenitors that are required for the production and maintenance of all differentiated cell types, including the germline. Neoblasts, originally defined as undifferentiated cells residing in the adult parenchyma, are frequently compared to embryonic stem cells yet their developmental origin remains obscure. We investigated the provenance of neoblasts during embryogenesis, and report that neoblasts arise from an anarchic, cycling population wholly responsible for production of all temporary and definitive organs during embryogenesis. Early embryonic cells are molecularly and functionally distinct from neoblasts: they express unique cohorts of early embryo enriched transcripts and behave differently than neoblasts in cell transplantation assays. Neoblast lineages arise as organogenesis begins and are required for construction of all major organ systems during embryogenesis. These subpopulations are continuously generated during adulthood, where they act as agents of tissue homeostasis and regeneration.

Citing Articles

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A comparative analysis of planarian genomes reveals regulatory conservation in the face of rapid structural divergence.

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