Increasing the Reference Populations for the 55 AISNP Panel: the Need and Benefits

Overview

Journal Int J Legal Med

Specialty Forensic Sciences

Date 2017 Jan 11

PMID 28070634

Citations 14

Authors

Andrew J Pakstis

Longli Kang

Lijun Liu

Zhiying Zhang

Tianbo Jin

Elena L Grigorenko

Frank R Wendt

Bruce Budowle

Sibte Hadi

Mariam Salam Al Qahtani

Niels Morling

Helle Smidt Mogensen

Goncalo E Themudo

Usha Soundararajan

Haseena Rajeevan

Judith R Kidd

Kenneth K Kidd

Affiliations

Soon will be listed here.

Abstract

Ancestry inference for an individual can only be as good as the reference populations with allele frequency data on the SNPs being used. If the most relevant ancestral population(s) does not have data available for the SNPs studied, then analyses based on DNA evidence may indicate a quite distantly related population, albeit one among the more closely related of the existing reference populations. We have added reference population allele frequencies for 14 additional population samples (with >1100 individuals studied) to the 125 population samples previously published for the Kidd Lab 55 AISNP panel. Allele frequencies are now publicly available for all 55 SNPs in ALFRED and FROG-kb for a total of 139 population samples. This Kidd Lab panel of 55 ancestry informative SNPs has been incorporated in commercial kits by both ThermoFisher Scientific and Illumina for massively parallel sequencing. Researchers employing those kits will find the enhanced set of reference populations useful.

Citing Articles

Biogeographical Ancestry Analyses Using the ForenSeq DNA Signature Prep Kit and Multiple Prediction Tools.

Salvo N, Olsen G, Berg T, Janssen K Genes (Basel). 2024; 15(4).

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Forensic biogeographical ancestry inference: recent insights and current trends.

Wen Y, Liu J, Su Y, Chen X, Hou Y, Liao L Genes Genomics. 2023; 45(10):1229-1238.

PMID: 37081293 DOI: 10.1007/s13258-023-01387-5.

State of the Art for Microhaplotypes.

Kidd K, Pakstis A Genes (Basel). 2022; 13(8).

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North Asian population relationships in a global context.

Kidd K, Evsanaa B, Togtokh A, Brissenden J, Roscoe J, Dogan M Sci Rep. 2022; 12(1):7214.

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Review of the Forensic Applicability of Biostatistical Methods for Inferring Ancestry from Autosomal Genetic Markers.

Tvedebrink T Genes (Basel). 2022; 13(1).

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