Association of TNF-α Gene Polymorphisms with Production of Protein and Susceptibility to Chronic Hepatitis B Infection in the South East Iranian Population

Overview

Journal Hepat Mon

Publisher Brieflands

Specialty Gastroenterology

Date 2017 Jan 11

PMID 28070201

Citations 10

Authors

Zahra Heidari

Bita Moudi

Hamidreza Mahmoudzadeh Sagheb

Mehrnoosh Moudi

Affiliations

Soon will be listed here.

Abstract

Background: The host genetic background regulates the natural history of chronic hepatitis B virus (HBV) infection.

Objectives: The aim of this study was to investigate the association between TNF-α gene polymorphism in the promoter region and susceptibility to chronic hepatitis B virus infection.

Methods: Four polymorphisms of TNF-α gene including -238 A/G, -308 A/G, -857 C/T, and -863 A/C were analyzed by PCR-RFLP in 100 chronic HBV infected patients (HBV group), 40 spontaneously recovered HBV subjects (SR group), and 100 healthy controls (C group). Also, serum levels of protein were monitored.

Results: The study showed that the existence of -308 G, -857 C, and -863 A alleles signiﬁcantly increased susceptibility to chronic HBV infection. In addition, GGCA haplotype had a higher frequency in HBV patients than C and SR groups that might be related to the natural history of the infection. Chronic HBV patients with -308 GG, -857 CC, and -863 AA genotypes had lower serum levels of TNF-α compared to those with other genotypes.

Conclusions: The results indicated that there was a positive association between susceptibility to chronic HBV infection and TNF-α polymorphism. In addition, HBV patients carrying -308 GG, -857 CC, and -863 AA genotypes with lower serum levels of TNF-α had an increased risk of infection.

Citing Articles

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Host cytokine genetic polymorphisms in a selected population of persons living with hepatitis B virus infection in the central region of Ghana.

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Kencono Wungu C, Ariyanto F, Prabowo G, Soetjipto , Handajani R BMC Cancer. 2020; 20(1):1134.

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