Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading

Overview

Journal Int J Rheumatol

Publisher Wiley

Specialty Rheumatology

Date 2017 Jan 11

PMID 28070192

Citations 17

Authors

Jirun Apinun

Panjana Sengprasert

Pongsak Yuktanandana

Srihatach Ngarmukos

Aree Tanavalee

Rangsima Reantragoon

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading. Our results show that CD8+ T cells are increased in osteoarthritic patients with higher radiographic grading. When peripheral blood CD8+ T cells were examined, we show that CD8+ T cells possess a significantly higher level of activation than its CD4+ T cell counterpart ( < 0.0001). Our results suggest a role for CD8+ T cells and recruitment of these activated circulating peripheral blood CD8+ T cells to the knee triggering local inflammation within the knee joint.

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References

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier J, Fahmi H . Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2010; 7(1):33-42. DOI: 10.1038/nrrheum.2010.196. View

Kellgren J, Lawrence J . Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16(4):494-502. PMC: 1006995. DOI: 10.1136/ard.16.4.494. View

Nakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, Gomez-Reino J, Furuichi T . New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. PLoS One. 2010; 5(3):e9723. PMC: 2841168. DOI: 10.1371/journal.pone.0009723. View

AHLBACK S . Osteoarthrosis of the knee. A radiographic investigation. Acta Radiol Diagn (Stockh). 1968; :Suppl 277:7-72. View

Klein-Wieringa I, de Lange-Brokaar B, Yusuf E, Andersen S, Kwekkeboom J, Kroon H . Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad. J Rheumatol. 2016; 43(4):771-8. DOI: 10.3899/jrheum.151068. View

Han W, Cai S, Liu Z, Jin X, Wang X, Antony B . Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?. Arthritis Res Ther. 2014; 16(4):R145. PMC: 4227074. DOI: 10.1186/ar4607. View

Rejeski W, Shumaker S . Knee osteoarthritis and health-related quality of life. Med Sci Sports Exerc. 1994; 26(12):1441-5. View

Wang Q, Rozelle A, Lepus C, Scanzello C, Song J, Larsen D . Identification of a central role for complement in osteoarthritis. Nat Med. 2011; 17(12):1674-9. PMC: 3257059. DOI: 10.1038/nm.2543. View

Ioan-Facsinay A, Kloppenburg M . An emerging player in knee osteoarthritis: the infrapatellar fat pad. Arthritis Res Ther. 2013; 15(6):225. PMC: 3979009. DOI: 10.1186/ar4422. View

10.

Murphy L, Helmick C . The impact of osteoarthritis in the United States: a population-health perspective. Am J Nurs. 2012; 112(3 Suppl 1):S13-9. DOI: 10.1097/01.NAJ.0000412646.80054.21. View

11.

Klein-Wieringa I, Kloppenburg M, Bastiaansen-Jenniskens Y, Yusuf E, Kwekkeboom J, El-Bannoudi H . The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis. 2011; 70(5):851-7. DOI: 10.1136/ard.2010.140046. View

12.

Loeser R, Goldring S, Scanzello C, Goldring M . Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012; 64(6):1697-707. PMC: 3366018. DOI: 10.1002/art.34453. View

13.

Benito M, Veale D, FitzGerald O, van den Berg W, Bresnihan B . Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005; 64(9):1263-7. PMC: 1755629. DOI: 10.1136/ard.2004.025270. View

14.

Pawlowska J, Mikosik A, Soroczynska-Cybula M, Jozwik A, Luczkiewicz P, Mazurkiewicz S . Different distribution of CD4 and CD8 T cells in synovial membrane and peripheral blood of rheumatoid arthritis and osteoarthritis patients. Folia Histochem Cytobiol. 2010; 47(4):627-32. DOI: 10.2478/v10042-009-0117-9. View

15.

Saito I, Koshino T, Nakashima K, Uesugi M, Saito T . Increased cellular infiltrate in inflammatory synovia of osteoarthritic knees. Osteoarthritis Cartilage. 2002; 10(2):156-62. DOI: 10.1053/joca.2001.0494. View

16.

Steiner G, Tohidast-Akrad M, Witzmann G, Vesely M, Studnicka-Benke A, Gal A . Cytokine production by synovial T cells in rheumatoid arthritis. Rheumatology (Oxford). 1999; 38(3):202-13. DOI: 10.1093/rheumatology/38.3.202. View

17.

Wakitani S, Imoto K, Mazuka T, Kim S, Murata N, Yoneda M . Japanese generalised osteoarthritis was associated with HLA class I--a study of HLA-A, B, Cw, DQ, DR in 72 patients. Clin Rheumatol. 2002; 20(6):417-9. DOI: 10.1007/s100670170006. View

18.

Torisu T, Fujikawa Y, Yano H, Masumi S . Association of HLA-DR and HLA-DQ antigens with congenital dislocation and dysplastic osteoarthritis of the hip joints in Japanese people. Arthritis Rheum. 1993; 36(6):815-8. DOI: 10.1002/art.1780360612. View

19.

Moos V, Menard J, Sieper J, Sparmann M, Muller B . Association of HLA-DRB1*02 with osteoarthritis in a cohort of 106 patients. Rheumatology (Oxford). 2002; 41(6):666-9. DOI: 10.1093/rheumatology/41.6.666. View

20.

Scanzello C, Loeser R . Editorial: inflammatory activity in symptomatic knee osteoarthritis: not all inflammation is local. Arthritis Rheumatol. 2015; 67(11):2797-800. PMC: 5093334. DOI: 10.1002/art.39304. View