Non-linear Parameters of Specific Resistance Loops to Characterise Obstructive Airways Diseases

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2017 Jan 11

PMID 28068996

Citations 7

Authors

Marko Topalovic

Vasileios Exadaktylos

Thierry Troosters

Geert Celis

Jean-Marie Aerts

Wim Janssens

Affiliations

Soon will be listed here.

Abstract

Background: Specific resistance loops appear in different shapes influenced by different resistive properties of the airways, yet their descriptive ability is compressed to a single parameter - its slope. We aimed to develop new parameters reflecting the various shapes of the loop and to explore their potential in the characterisation of obstructive airways diseases.

Methods: Our study included 134 subjects: Healthy controls (N = 22), Asthma with non-obstructive lung function (N = 22) and COPD of all disease stages (N = 90). Different shapes were described by geometrical and second-order transfer function parameters.

Results: Our parameters demonstrated no difference between asthma and healthy controls groups, but were significantly different (p < 0.0001) from the patients with COPD. Grouping mild COPD subjects by an open or not-open shape of the resistance loop revealed significant differences of loop parameters and classical lung function parameters. Multiple logistic regression indicated RV/TLC as the only predictor of loop opening with OR = 1.157, 95% CI (1.064-1.267), p-value = 0.0006 and R = 0.35. Inducing airway narrowing in asthma gave equal shape measures as in COPD non-openers, but with a decreased slope (p < 0.0001).

Conclusion: This study introduces new parameters calculated from the resistance loops which may correlate with different phenotypes of obstructive airways diseases.

Citing Articles

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Investigation of the Methodology of Specific Airway Resistance Measurements in COPD.

Dean J, Singh D Int J Chron Obstruct Pulmon Dis. 2023; 18:2555-2563.

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References

Criee C, Sorichter S, Smith H, Kardos P, Merget R, Heise D . Body plethysmography--its principles and clinical use. Respir Med. 2011; 105(7):959-71. DOI: 10.1016/j.rmed.2011.02.006. View

Matthys H, Orth U . Comparative measurements of airway resistance. Respiration. 1975; 32(2):121-34. DOI: 10.1159/000193642. View

Bateman E, Hurd S, Barnes P, Bousquet J, Drazen J, Fitzgerald J . Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008; 31(1):143-78. DOI: 10.1183/09031936.00138707. View

Rubinsztajn R, Przybylowski T, Maskey-Warzechowska M, Paplinska-Goryca M, Karwat K, Nejman-Gryz P . Correlation between hyperinflation defined as an elevated RV/TLC ratio and body composition and cytokine profile in patients with chronic obstructive pulmonary disease. Pneumonol Alergol Pol. 2015; 83(2):120-5. DOI: 10.5603/PiAP.2015.0019. View

Tomalak W, Peslin R, Duvivier C . Variations in airways impedance during respiratory cycle derived from combined measurements of input and transfer impedances. Eur Respir J. 1999; 12(6):1436-41. DOI: 10.1183/09031936.98.12061436. View

Wagnetz U, Roberts H, Chung T, Patsios D, Chapman K, Paul N . Dynamic airway evaluation with volume CT: initial experience. Can Assoc Radiol J. 2010; 61(2):90-7. DOI: 10.1016/j.carj.2009.11.007. View

Gibson G . Pulmonary hyperinflation a clinical overview. Eur Respir J. 1996; 9(12):2640-9. DOI: 10.1183/09031936.96.09122640. View

Dellaca R, Duffy N, Pompilio P, Aliverti A, Koulouris N, Pedotti A . Expiratory flow limitation detected by forced oscillation and negative expiratory pressure. Eur Respir J. 2006; 29(2):363-74. DOI: 10.1183/09031936.00038006. View

Crapo R, Casaburi R, Coates A, Enright P, Hankinson J, Irvin C . Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 2000; 161(1):309-29. DOI: 10.1164/ajrccm.161.1.ats11-99. View

10.

Peslin R, Gallina C, Rotger M . Methodological factors in the variability of lung volume and specific airway resistance measured by body plethysmography. Bull Eur Physiopathol Respir. 1987; 23(4):323-7. View

11.

Wielputz M, Eberhardt R, Puderbach M, Weinheimer O, Kauczor H, Heussel C . Simultaneous assessment of airway instability and respiratory dynamics with low-dose 4D-CT in chronic obstructive pulmonary disease: a technical note. Respiration. 2014; 87(4):294-300. DOI: 10.1159/000357448. View

12.

Decramer M, Selroos O . Asthma and COPD: differences and similarities. With special reference to the usefulness of budesonide/formoterol in a single inhaler (Symbicort) in both diseases. Int J Clin Pract. 2005; 59(4):385-98. DOI: 10.1111/j.1368-5031.2005.00509.x. View

13.

ODonnell D, Fluge T, Gerken F, Hamilton A, Webb K, Aguilaniu B . Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J. 2004; 23(6):832-40. DOI: 10.1183/09031936.04.00116004. View

14.

Lougheed M, Fisher T, ODonnell D . Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception. Chest. 2006; 130(4):1072-81. DOI: 10.1378/chest.130.4.1072. View

15.

Topalovic M, Derom E, Osadnik C, Troosters T, Decramer M, Janssens W . Airways resistance and specific conductance for the diagnosis of obstructive airways diseases. Respir Res. 2015; 16:88. PMC: 4509748. DOI: 10.1186/s12931-015-0252-0. View

16.

Miller M, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A . Standardisation of spirometry. Eur Respir J. 2005; 26(2):319-38. DOI: 10.1183/09031936.05.00034805. View

17.

Miller A, Thornton J, Warshaw R, Anderson H, Teirstein A, SELIKOFF I . Single breath diffusing capacity in a representative sample of the population of Michigan, a large industrial state. Predicted values, lower limits of normal, and frequencies of abnormality by smoking history. Am Rev Respir Dis. 1983; 127(3):270-7. DOI: 10.1164/arrd.1983.127.3.270. View

18.

Quanjer P, Tammeling G, Cotes J, Pedersen O, Peslin R, Yernault J . [Lung volumes and forced ventilatory flows. Work Group on Standardization of Respiratory Function Tests. European Community for Coal and Steel. Official position of the European Respiratory Society]. Rev Mal Respir. 1994; 11 Suppl 3:5-40. View

19.

Islam M, Ulmer W . Diagnostic value of "closing volume" in comparison to "airway resistance-lung volume plot". Respiration. 1974; 31(6):449-58. DOI: 10.1159/000193618. View

20.

Vestbo J, Hurd S, Agusti A, Jones P, Vogelmeier C, Anzueto A . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2012; 187(4):347-65. DOI: 10.1164/rccm.201204-0596PP. View