OleD Loki As a Catalyst for Tertiary Amine and Hydroxamate Glycosylation

Overview

Journal Chembiochem

Specialty Biochemistry

Date 2017 Jan 10

PMID 28067448

Citations 3

Authors

Ryan R Hughes

Khaled A Shaaban

Jianjun Zhang

Hongnan Cao

George N Phillips Jr

Jon S Thorson

Affiliations

Soon will be listed here.

Abstract

We describe the ability of an engineered glycosyltransferase (OleD Loki) to catalyze the N-glycosylation of tertiary-amine-containing drugs and trichostatin hydroxamate glycosyl ester formation. As such, this study highlights the first bacterial model catalyst for tertiary-amine N-glycosylation and further expands the substrate scope and synthetic potential of engineered OleDs. In addition, this work could open the door to the discovery of similar capabilities among other permissive bacterial glycosyltransferases.

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