The Contraction Fraction (CF) in Myocardial Studies with Technetium-99m-isonitrile (MIBI)--correlations with Radionuclide Ventriculography and Infarct Size Measured by SPECT

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1989 Jan 1

PMID 2806328

Citations 4

Authors

M Clausen

E Henze

A Schmidt

R Weller

R Lietzenmayer

D Hellwig

F BITTER

P Hildebrand

V Hombach

W E ADAM

Affiliations

Soon will be listed here.

Abstract

Criteria for the detection of coronary artery disease in nuclear cardiology include visualization of perfusion defects and functional impairment of contraction. The purpose of this study is to combine both methods in one procedure with the new myocardial perfusion tracer, 99mTc-methoxy-isobutyl-isonitril (MIBI), reducing time and radiation burden to the patient. Following an uncomplicated recovery, ten patients with first myocardial infarction participated in this study. Radionuclide ventriculography (RNV) was performed at rest and during exercise. Within 2-3 days, 370 MBq 99mTc-MIBI were injected and SPECT acquisition commenced 1 h later. Data processing included a scar image in polar coordinates. Areas of significantly reduced tracer uptake were expressed as a percentage of the total myocardial area. Directly following SPECT, resting and maximum exercise gated planar LAO images were recorded and the contraction was quantified. The concept of the contraction fraction (CF) rested on the end systolic change in count distribution: their increase in density and their centripetal concentration. For comparison, geometrical inner edge detection techniques were also applied. All algorithms for describing an EF equivalent were verified by computer simulations, showing a perfect correlation over a wide range of preset EFs. When applied to the patient studies only the non geometric methods revealed a good correlation with the ejection fraction (EF) obtained by RNV, and with the infarct size measured by SPECT.(ABSTRACT TRUNCATED AT 250 WORDS)

Citing Articles

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European multi-centre comparison of thallium 201 and technetium 99m methoxyisobutylisonitrile in ischaemic heart disease.

Maisey M, Lowry A, Bischof-Delaloye A, Fridrich R, Inglese E, Khalil M Eur J Nucl Med. 1990; 16(12):869-72.

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Reproducibility of quantitative hexakis-2-methoxyisobutylisonitrile single photon emission tomography in stable coronary artery disease.

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Amplitude analysis of stress technetium-99m methoxy isobutylisonitrile images in coronary artery disease.

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