CRYPTOCHROME Mediates Behavioral Executive Choice in Response to UV Light

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2017 Jan 8

PMID 28062690

Citations 23

Authors

Lisa S Baik

Keri J Fogle

Logan Roberts

Alexis M Galschiodt

Joshua A Chevez

Yocelyn Recinos

Vinh Nguy

Todd C Holmes

Affiliations

Soon will be listed here.

Abstract

Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. To determine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiological responses to UV light. CRY and opsin-based external photoreceptor systems cooperate for UV light-evoked acute responses. CRY mediates behavioral avoidance responses related to executive choice, consistent with its expression in central brain neurons.

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