Synthesis and Insecticidal Activity of Acridone Derivatives to Aedes Aegypti and Culex Quinquefasciatus Larvae and Non-target Aquatic Species

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jan 7

PMID 28059104

Authors

Selvaraj Mohana Roopan

Annadurai Bharathi

Naif Abdullah Al-Dhabi

Mariadhas Valan Arasu

G Madhumitha

Affiliations

Soon will be listed here.

Abstract

A serious Mosquito borne yellow fever is one of the grave diseases which affect the major population. Since there is no specific treatment for yellow fever, there is a necessity to develop an effective agent. The series of acridinone analogues 3 to 5 were synthesized with help of non-conventional microwave heating and confirmed by respective spectral characterization. 5c and 3b showed highest activity to kill 90% of larvae against A. aegypti and C. quinquefasciatus, respectively. Also the active products were treated to check the mortality of non-target aquatic species. Through the reports of the larvicidal bioassay, compounds 3b against C. quinquefasciatus whereas 5c against A. aegypti were found to be more active. By keeping this as a platform, further extension of the work can be done to find out a valuable drug for controlling disease vectors.

References

Denny W . Acridine derivatives as chemotherapeutic agents. Curr Med Chem. 2002; 9(18):1655-65. DOI: 10.2174/0929867023369277. View

Subashini R, Bharathi A, Roopan S, Rajakumar G, Rahuman A, Gullanki P . Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues. Spectrochim Acta A Mol Biomol Spectrosc. 2012; 95:442-5. DOI: 10.1016/j.saa.2012.04.015. View

Pasquale G, Romanelli G, Autino J, Garcia J, Ortiz E, Duchowicz P . Quantitative structure-activity relationships of mosquito larvicidal chalcone derivatives. J Agric Food Chem. 2012; 60(2):692-7. DOI: 10.1021/jf203374r. View

Tolle M . Mosquito-borne diseases. Curr Probl Pediatr Adolesc Health Care. 2009; 39(4):97-140. DOI: 10.1016/j.cppeds.2009.01.001. View

Kogan , Hagedorn . Polyamines, and effects from reducing their synthesis during egg development in the yellow fever mosquito, Aedes aegypti. J Insect Physiol. 2000; 46(7):1079-1095. DOI: 10.1016/s0022-1910(99)00084-0. View

Li Y, Kuwano E, Noriega F . 1,5-Disubstituted imidazoles inhibit juvenile hormone biosynthesis by the corpora allata of the mosquito Aedes aegypti. J Insect Physiol. 2003; 49(11):1005-11. DOI: 10.1016/s0022-1910(03)00183-5. View

Tomar V, Bhattacharjee G, Kamaluddin , Rajakumar S, Srivastava K, Puri S . Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity. Eur J Med Chem. 2009; 45(2):745-51. DOI: 10.1016/j.ejmech.2009.11.022. View

da Silva-Alves D, Dos Anjos J, Cavalcante N, Santos G, Navarro D, Srivastava R . Larvicidal isoxazoles: Synthesis and their effective susceptibility towards Aedes aegypti larvae. Bioorg Med Chem. 2013; 21(4):940-7. DOI: 10.1016/j.bmc.2012.12.006. View

Tarasiuk J, Majewska E, Seksek O, Rogacka D, Antonini I, Garnier-Suillerot A . The role of structural factors in the kinetics of cellular uptake of pyrazoloacridines and pyrazolopyrimidoacridines: implications for overcoming multidrug resistance towards leukaemia K562/DOX cells. Biochem Pharmacol. 2004; 68(9):1815-23. DOI: 10.1016/j.bcp.2004.06.028. View

10.

Kumar A, Srivastava K, Raja Kumar S, Puri S, Chauhan P . Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents. Bioorg Med Chem Lett. 2010; 20(23):7059-63. DOI: 10.1016/j.bmcl.2010.09.107. View

11.

Yu X, Ramiandrasoa F, Guetzoyan L, Pradines B, Quintino E, Gadelle D . Synthesis and biological evaluation of acridine derivatives as antimalarial agents. ChemMedChem. 2012; 7(4):587-605. DOI: 10.1002/cmdc.201100554. View

12.

Julander J . Experimental therapies for yellow fever. Antiviral Res. 2012; 97(2):169-79. PMC: 3563926. DOI: 10.1016/j.antiviral.2012.12.002. View