Scaling of Titanium Implants Entrains Inflammation-induced Osteolysis

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jan 7

PMID 28059080

Citations 46

Authors

Michal Eger

Nir Sterer

Tamar Liron

David Kohavi

Yankel Gabet

Affiliations

Soon will be listed here.

Abstract

With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis. The number of released particles and their chemical composition and nanotopography had a significant effect on the inflammatory response. Sandblasted surfaces released the highest number of particles with the greatest nanoroughness properties. Particles from sandblasted/acid-etched discs induced a milder inflammatory response than those from sandblasted discs but a stronger inflammatory response than those from machined discs. Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants.

Citing Articles

Impact of Glow-Discharge Nitriding Technology on the Properties of 3D-Printed Grade 2 Titanium Alloy.

Kaminski J, Sitek R, Adamczyk-Cieslak B, Kulikowski K Materials (Basel). 2024; 17(18).

PMID: 39336333 PMC: 11433006. DOI: 10.3390/ma17184592.

Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids.

Zhao X, Li N, Zhang Z, Hong J, Zhang X, Hao Y J Nanobiotechnology. 2024; 22(1):500.

PMID: 39169401 PMC: 11337604. DOI: 10.1186/s12951-024-02759-z.

Peri-implantitis induction and resolution around zirconia versus titanium implants.

Esplin K, Tsai Y, Vela K, Diogenes A, Hachem L, Palaiologou A J Periodontol. 2024; 95(12):1180-1189.

PMID: 39003566 PMC: 11708443. DOI: 10.1002/JPER.23-0573.

Assessing the Impact of Various Decontamination Instruments on Titanium and Zirconia Dental Implants: An In Vitro Study.

Vierling L, Liu C, Wiedemeier D, Gubler A, Schmidlin P Dent J (Basel). 2024; 12(5).

PMID: 38786534 PMC: 11119916. DOI: 10.3390/dj12050136.

Quantity and Size of Titanium Particles Released from Different Mechanical Decontamination Procedures on Titanium Discs: An In Vitro Study.

Kao A, Tawse-Smith A, Ma S, Duncan W, Reid M, Atieh M Dent J (Basel). 2024; 12(5).

PMID: 38786521 PMC: 11119952. DOI: 10.3390/dj12050123.

References

Chen W, Li Z, Guo Y, Zhou Y, Zhang Y, Luo G . Wear Particles Impair Antimicrobial Activity Via Suppression of Reactive Oxygen Species Generation and ERK1/2 Phosphorylation in Activated Macrophages. Inflammation. 2015; 38(3):1289-96. DOI: 10.1007/s10753-014-0099-4. View

Kudo O, Fujikawa Y, Itonaga I, Sabokbar A, Torisu T, Athanasou N . Proinflammatory cytokine (TNFalpha/IL-1alpha) induction of human osteoclast formation. J Pathol. 2002; 198(2):220-7. DOI: 10.1002/path.1190. View

Takeshita S, Kaji K, Kudo A . Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res. 2000; 15(8):1477-88. DOI: 10.1359/jbmr.2000.15.8.1477. View

Schmage P, Thielemann J, Nergiz I, Scorziello T, Pfeiffer P . Effects of 10 cleaning instruments on four different implant surfaces. Int J Oral Maxillofac Implants. 2012; 27(2):308-17. View

Ngoh E, Weisser S, Lo Y, Kozicky L, Jen R, Brugger H . Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease. Gastroenterology. 2015; 150(2):465-76. DOI: 10.1053/j.gastro.2015.09.049. View

Esposito M, Grusovin M, Worthington H . Interventions for replacing missing teeth: treatment of peri-implantitis. Cochrane Database Syst Rev. 2012; 1:CD004970. PMC: 6786958. DOI: 10.1002/14651858.CD004970.pub5. View

Schwartz Z, Martin J, Dean D, Simpson J, Cochran D, Boyan B . Effect of titanium surface roughness on chondrocyte proliferation, matrix production, and differentiation depends on the state of cell maturation. J Biomed Mater Res. 1996; 30(2):145-55. DOI: 10.1002/(SICI)1097-4636(199602)30:2<145::AID-JBM3>3.0.CO;2-R. View

Ingham E, Fisher J . The role of macrophages in osteolysis of total joint replacement. Biomaterials. 2004; 26(11):1271-86. DOI: 10.1016/j.biomaterials.2004.04.035. View

Zreiqat H, Valenzuela S, Nissan B, Roest R, Knabe C, Radlanski R . The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts. Biomaterials. 2005; 26(36):7579-86. DOI: 10.1016/j.biomaterials.2005.05.024. View

10.

Lee S, Sharma A, Choi B, Jung J, Chang J, Park S . The effect of TNFα secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT/BMP signaling in osteoprogenitor cells. Biomaterials. 2012; 33(17):4251-63. DOI: 10.1016/j.biomaterials.2012.03.005. View

11.

Ruegsegger P, Koller B, Muller R . A microtomographic system for the nondestructive evaluation of bone architecture. Calcif Tissue Int. 1996; 58(1):24-9. DOI: 10.1007/BF02509542. View

12.

Schmage P, Kahili F, Nergiz I, Scorziello T, Platzer U, Pfeiffer P . Cleaning effectiveness of implant prophylaxis instruments. Int J Oral Maxillofac Implants. 2014; 29(2):331-7. DOI: 10.11607/jomi.2524. View

13.

Schuler M, Rh Owen G, Hamilton D, de Wild M, Textor M, Brunette D . Biomimetic modification of titanium dental implant model surfaces using the RGDSP-peptide sequence: a cell morphology study. Biomaterials. 2006; 27(21):4003-15. DOI: 10.1016/j.biomaterials.2006.03.009. View

14.

Hiram-Bab S, Liron T, Deshet-Unger N, Mittelman M, Gassmann M, Rauner M . Erythropoietin directly stimulates osteoclast precursors and induces bone loss. FASEB J. 2015; 29(5):1890-900. DOI: 10.1096/fj.14-259085. View

15.

Esposito M, Coulthard P, Thomsen P, Worthington H . Interventions for replacing missing teeth: different types of dental implants. Cochrane Database Syst Rev. 2005; (1):CD003815. DOI: 10.1002/14651858.CD003815.pub2. View

16.

Le Guillou-Buffello D, Bareille R, Gindre M, Sewing A, Laugier P, Amedee J . Additive effect of RGD coating to functionalized titanium surfaces on human osteoprogenitor cell adhesion and spreading. Tissue Eng Part A. 2008; 14(8):1445-55. DOI: 10.1089/ten.tea.2007.0292. View

17.

Hildebrand T, Laib A, Muller R, Dequeker J, Ruegsegger P . Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res. 1999; 14(7):1167-74. DOI: 10.1359/jbmr.1999.14.7.1167. View

18.

Mombelli A, Muller N, Cionca N . The epidemiology of peri-implantitis. Clin Oral Implants Res. 2012; 23 Suppl 6:67-76. DOI: 10.1111/j.1600-0501.2012.02541.x. View

19.

Heitz-Mayfield L, Mombelli A . The therapy of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants. 2014; 29 Suppl:325-45. DOI: 10.11607/jomi.2014suppl.g5.3. View

20.

Revell P . The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses. J R Soc Interface. 2008; 5(28):1263-78. PMC: 2607446. DOI: 10.1098/rsif.2008.0142. View