Increased Autophagy in Fibroblast-like Synoviocytes Leads to Immune Enhancement Potential in Rheumatoid Arthritis

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Jan 6

PMID 28053286

Citations 21

Authors

Ru Yang

Yingzi Zhang

Lin Wang

Ji Hu

Jian Wen

Leixi Xue

Mei Tang

Zhichun Liu

Jinxiang Fu

Affiliations

Soon will be listed here.

Abstract

The incidence of rheumatoid arthritis (RA) has been reported to be correlated with a disorder of immunregulation. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play an important role in regulating the local immune microenvironment. However, the potential mechanism of RA-FLS in regulating the immnue response is not clearly understood. In this study, we demonstrated that the expression of HIF-1α was significantly up-regulated in rheumatoid arthritis tissue which indicated that the hypoxia condition in the microenvironment. We also observed that RA-FLSs demonstrated the potential to up-regulate immune activation. Meanwhile, the level of autophagy increased in RA-FLSs compared with control group. Besides that, the expression of IL-6 was up-regulated not only in RA-FLSs but also in the fibroblasts that treated with hypoxia condition. Accordingly, we found that autophagy inhibitiors could effectively inhibit the immune activation function of RA-FLSs medicated by IL-6. Taken together, the results we demonstrated above indicated that the hypoxia microenvironment could effectively induce the incidence of autophagy and then lead to the immune activation function of RA-FLSs medicated by IL-6.

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