The Papillomavirus Episteme: a Major Update to the Papillomavirus Sequence Database

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2017 Jan 6

PMID 28053164

Citations 210

Authors

Koenraad Van Doorslaer

Zhiwen Li

Sandhya Xirasagar

Piet Maes

David Kaminsky

David Liou

Qiang Sun

Ramandeep Kaur

Yentram Huyen

Alison A McBride

Affiliations

Soon will be listed here.

Abstract

The Papillomavirus Episteme (PaVE) is a database of curated papillomavirus genomic sequences, accompanied by web-based sequence analysis tools. This update describes the addition of major new features. The papillomavirus genomes within PaVE have been further annotated, and now includes the major spliced mRNA transcripts. Viral genes and transcripts can be visualized on both linear and circular genome browsers. Evolutionary relationships among PaVE reference protein sequences can be analysed using multiple sequence alignments and phylogenetic trees. To assist in viral discovery, PaVE offers a typing tool; a simplified algorithm to determine whether a newly sequenced virus is novel. PaVE also now contains an image library containing gross clinical and histopathological images of papillomavirus infected lesions. Database URL: https://pave.niaid.nih.gov/.

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