Endogenously Released Neuropeptide Y Suppresses Hippocampal Short-Term Facilitation and Is Impaired by Stress-Induced Anxiety

Overview

Journal J Neurosci

Specialty Neurology

Date 2017 Jan 6

PMID 28053027

Citations 29

Authors

Qin Li

Aundrea F Bartley

Lynn E Dobrunz

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Neuropeptide Y (NPY) has robust anxiolytic properties, and its levels are reduced in patients with post-traumatic stress disorder. The effects of endogenously released NPY during physiologically relevant stimulation, and the impact of stress-induced reductions in NPY on circuit function, are unknown. By demonstrating that NPY release modulates hippocampal synaptic plasticity and is impaired by predator scent stress, our results provide a novel mechanism by which stress-induced anxiety alters circuit function. These studies fill an important gap in knowledge between the molecular and behavioral effects of NPY. This article also advances the understanding of NPY+ cells and the factors that regulate their spiking, which could pave the way for new therapeutic targets to increase endogenous NPY release in patients in a spatially and temporally appropriate manner.

Citing Articles

Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.

Silveira M, Herrera Y, Beebe N, Schofield B, Roberts M J Neurophysiol. 2024; 132(2):573-588.

PMID: 38988288 PMC: 11427056. DOI: 10.1152/jn.00131.2024.

Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.

Silveira M, Herrera Y, Beebe N, Schofield B, Roberts M bioRxiv. 2024; .

PMID: 38585909 PMC: 10996674. DOI: 10.1101/2024.03.27.587042.

Neuropeptide Y Signaling Regulates Recurrent Excitation in the Auditory Midbrain.

Silveira M, Drotos A, Pirrone T, Versalle T, Bock A, Roberts M J Neurosci. 2023; 43(45):7626-7641.

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Detection of endogenous NPY release determined by novel GRAB sensor in cultured cortical neurons.

Christensen E, Konomi-Pilkati A, Rombach J, Comaposada-Baro R, Wang H, Li Y Front Cell Neurosci. 2023; 17:1221147.

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