Modulation of MicroRNA-mRNA Target Pairs by Human Papillomavirus 16 Oncoproteins

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2017 Jan 4

PMID 28049151

Citations 47

Authors

Mallory E Harden

Nripesh Prasad

Anthony Griffiths

Karl Munger

Affiliations

Soon will be listed here.

Abstract

Importance: High-risk human papillomaviruses (HPVs) are the causative agents of almost all cervical cancers and many other cancers, including anal, vaginal, vulvar, penile, and oropharyngeal cancers. Despite the availability of efficacious HPV vaccines, it is critical to determine how HPVs cause cancer, as many people remain unvaccinated and the vaccine does not prevent cancer development in individuals who are already infected. Two HPV proteins, E6 and E7, are the major drivers of cancer development, and much remains to be learned about how the expression of these viral proteins reprograms infected cells, ultimately resulting in cancer development. Small, noncoding human RNAs, termed microRNAs (miRs), regulate gene expression and have been implicated in almost all human cancers, including HPV-associated cancers. Our study provides a comprehensive analysis of how E6 and E7 alter the expression of human miRs and how this potentially impacts cellular gene expression, which may contribute to cancer development.

Citing Articles

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