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Knock out of the NADPH Oxidase Nox4 Has No Impact on Life Span in Mice

Overview
Journal Redox Biol
Specialties Biology
Cell Biology
Endocrinology
Date 2016 Dec 31
PMID 28038425
Citations 15
Authors
Flavia Rezende
Christoph Schurmann
Susanne Schutz
Sabine Harenkamp
Eva Herrmann
Michael Seimetz
Norbert Weissmann
Katrin Schroder
Affiliations
Soon will be listed here.
Abstract

The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice.

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