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Preparation and Characterization of Poly (hydroxy Butyrate)/chitosan Blend Scaffolds for Tissue Engineering Applications

Overview
Journal Adv Biomed Res
Specialty Biomedical Engineering
Date 2016 Dec 29
PMID 28028517
Citations 5
Authors
Saeed Karbasi
Saied Nouri Khorasani
Somayeh Ebrahimi
Shahla Khalili
Farnoosh Fekrat
Davoud Sadeghi
Affiliations
Soon will be listed here.
Abstract

Background: Poly (hydroxy butyrate) (PHB) is a biodegradable and biocompatible polymer with good mechanical properties. This polymer could be a promising material for scaffolds if some features improve.

Materials And Methods: In the present work, new PHB/chitosan blend scaffolds were prepared as a three-dimensional substrate in cartilage tissue engineering. Chitosan in different weight percent was added to PHB and solved in trifluoroacetic acid. Statistical Taguchi method was employed in the design of experiments.

Results: The Fourier-transform infrared spectroscopy test revealed that the crystallization of PHB in these blends is suppressed with increasing the amount of chitosan. Scanning electron microscopy images showed a thin and rough top layer with a nodular structure, supported with a porous sub-layer in the surface of the scaffolds. degradation rate of the scaffolds was higher than pure PHB scaffolds. Maximum degradation rate has been seen for the scaffold with 90% wt. NaCl and 40% wt. chitosan.

Conclusions: The obtained results suggest that these newly developed PHB/chitosan blend scaffolds may serve as a three-dimensional substrate in cartilage tissue engineering.

Citing Articles

Biological and Oxidative Degradation of Ultrathin-Fibrous Nonwovens Based on Poly(lactic Acid)/Poly(3-Hydroxybutyrate) Blends.

Olkhov A, Mastalygina E, Ovchinnikov V, Kurnosov A, Popov A, Iordanskii A Int J Mol Sci. 2023; 24(9).

PMID: 37175689 PMC: 10178885. DOI: 10.3390/ijms24097979.

Biocomposite Materials Based on Poly(3-hydroxybutyrate) and Chitosan: A Review.

Zhuikova Y, Zhuikov V, Varlamov V Polymers (Basel). 2022; 14(24).

PMID: 36559916 PMC: 9782520. DOI: 10.3390/polym14245549.

An overview of biodegradable packaging in food industry.

Shaikh S, Yaqoob M, Aggarwal P Curr Res Food Sci. 2021; 4:503-520.

PMID: 34401747 PMC: 8349771. DOI: 10.1016/j.crfs.2021.07.005.

Recent Progress in Antimicrobial Nanomaterials.

Diez-Pascual A Nanomaterials (Basel). 2020; 10(11).

PMID: 33238368 PMC: 7700142. DOI: 10.3390/nano10112315.

Boron Nitride Doped Polyhydroxyalkanoate/Chitosan Nanocomposite for Antibacterial and Biological Applications.

Mukheem A, Shahabuddin S, Akbar N, Miskon A, Muhamad Sarih N, Sudesh K Nanomaterials (Basel). 2019; 9(4).

PMID: 31010071 PMC: 6523564. DOI: 10.3390/nano9040645.

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