Nodular Lymphoid Hyperplasia: A Marker of Low-grade Inflammation in Irritable Bowel Syndrome?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2016 Dec 29

PMID 28028368

Citations 4

Authors

Anna Chiara Piscaglia

Lucrezia Laterza

Valentina Cesario

Viviana Gerardi

Rosario Landi

Loris Riccardo Lopetuso

Giovanni Calo

Giovanna Fabbretti

Massimo Brisigotti

Maria Loredana Stefanelli

Antonio Gasbarrini

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the prevalence of nodular lymphoid hyperplasia (NLH) in adult patients undergoing colonoscopy and its association with known diseases.

Methods: We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome (IBS)-type symptoms or suspected inflammatory bowel disease (IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening. Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period.

Results: One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals (only 3%), while it was significantly more prevalent in symptomatic cases (32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis.

Conclusion: About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients.

Citing Articles

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Mucosal bacterial dysbiosis in patients with nodular lymphoid hyperplasia in the terminal ileum.

Jiang Q, Lu Y, Zhang M, Cui Z, Pei Z, Li W World J Gastroenterol. 2022; 28(8):811-824.

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Ileocolonic Lymphonodular Hyperplasia in Children Related to Etiologies Ranging from Food Hypersensitivity to Familial Mediterranean Fever.

Cakir M, Sag E, Saygin I, Orhan F Med Princ Pract. 2020; 29(5):473-479.

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