Chiral Nanoparticle As a New Efficient Antimicrobial Nanoagent

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2016 Dec 28

PMID 28026134

Citations 15

Authors

Qi Xin

Qian Liu

Lingling Geng

Qiaojun Fang

Jian Ru Gong

Affiliations

Soon will be listed here.

Abstract

d-type functionalized nanoparticles (NPs) can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing. In contrast, its L-type counterpart displays a negligible effect, indicating that the chiral structure of the functionalized NPs plays an essential role in their binding interaction with MurD and therefore the antibacterial activity.

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