Decreased Serum 25-hydroxyvitamin D Level Causes Interventricular Septal Hypertrophy in Patients on Peritoneal Dialysis: Cardiovascular Aspects of Endogenous Vitamin D Deficiency

Overview

Journal Int J Nephrol

Publisher Wiley

Specialty Nephrology

Date 2016 Dec 27

PMID 28018677

Authors

Bennur Esen

Irfan Sahin

Ahmet Engin Atay

Emel Saglam Gokmen

Ozlem Harmankaya Kaptanogullari

Murvet Yilmaz

Suat Hayri Kucuk

Serdar Kahvecioglu

Nurhan Seyahi

Affiliations

Soon will be listed here.

Abstract

. In the present study, we aimed to analyze the relation of vitamin D with echocardiographic indexes in patients with end stage renal disease (ESRD) receiving renal replacement therapy (RRT). . A total of 98 patients, 64 patients on hemodialysis (HD) (29F/35M, mean age 56.75 ± 18.63 years) and 34 age matched patients on peritoneal dialysis (PD) (21F/13M, mean age 58.11 ± 10.63 years), with similar duration of ESRD and RRT were enrolled into this cross-sectional study. Echocardiographic examination was performed after dialysis session at normovolemic status. Fasting blood samples were obtained before dialysis session. . Patients on PD and female patients in both groups had significantly lower level of 25-OH-D3 level when compared to patients on HD or male patients (: 0.0001 and : 0.0001). When all participants were considered, there was no significant association between 25-OH-D3 and echocardiographic parameters; however, in patients on PD, a significant negative correlation was determined between 25-OH-D3 and diastolic blood pressure, interventricular septal hypertrophy (ISH), and left ventricular mass index (LVMI) (: -0.424, : 0.012; : -0.508, : 0.004; : 0.489, : 0.04, resp.). . Low serum 25-hydroxyvitamin D levels is associated with ISH and LVMI in PD patients.

References

Kiani A, Fang H, Magder L, Petri M . Vitamin D deficiency does not predict progression of coronary artery calcium, carotid intima-media thickness or high-sensitivity C-reactive protein in systemic lupus erythematosus. Rheumatology (Oxford). 2013; 52(11):2071-6. PMC: 3798716. DOI: 10.1093/rheumatology/ket271. View

Mose F, Vase H, Larsen T, Kancir A, Kosierkiewic R, Jonczy B . Cardiovascular effects of cholecalciferol treatment in dialysis patients--a randomized controlled trial. BMC Nephrol. 2014; 15:50. PMC: 3994388. DOI: 10.1186/1471-2369-15-50. View

Xanthakis V, Enserro D, Murabito J, Polak J, Wollert K, Januzzi J . Ideal cardiovascular health: associations with biomarkers and subclinical disease and impact on incidence of cardiovascular disease in the Framingham Offspring Study. Circulation. 2014; 130(19):1676-83. DOI: 10.1161/CIRCULATIONAHA.114.009273. View

Block G, Port F . Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendations for a change in management. Am J Kidney Dis. 2000; 35(6):1226-37. DOI: 10.1016/s0272-6386(00)70064-3. View

. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis. 2003; 42(4 Suppl 3):S1-201. View

OConnell T, Berry J, Jarvis A, Somerman M, Simpson R . 1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy. Am J Physiol. 1997; 272(4 Pt 2):H1751-8. DOI: 10.1152/ajpheart.1997.272.4.H1751. View

Singh N, Sahni V, Garg D, Nair M . Effect of pharmacological suppression of secondary hyperparathyroidism on cardiovascular hemodynamics in predialysis CKD patients: A preliminary observation. Hemodial Int. 2007; 11(4):417-23. DOI: 10.1111/j.1542-4758.2007.00211.x. View

Uysal S, Kalayci A, Baysal K . Cardiac functions in children with vitamin D deficiency rickets. Pediatr Cardiol. 1999; 20(4):283-6. DOI: 10.1007/s002469900464. View

Yokoyama K, Nakashima A, Urashima M, Suga H, Mimura T, Kimura Y . Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes. PLoS One. 2012; 7(12):e51171. PMC: 3514263. DOI: 10.1371/journal.pone.0051171. View

10.

Drechsler C, Verduijn M, Pilz S, Dekker F, Krediet R, Ritz E . Vitamin D status and clinical outcomes in incident dialysis patients: results from the NECOSAD study. Nephrol Dial Transplant. 2010; 26(3):1024-32. DOI: 10.1093/ndt/gfq606. View

11.

Neil Thomas G, Hartaigh B, Bosch J, Pilz S, Loerbroks A, Kleber M . Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. Diabetes Care. 2012; 35(5):1158-64. PMC: 3329808. DOI: 10.2337/dc11-1714. View

12.

Lang R, Bierig M, Devereux R, Flachskampf F, Foster E, Pellikka P . Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of.... J Am Soc Echocardiogr. 2005; 18(12):1440-63. DOI: 10.1016/j.echo.2005.10.005. View

13.

Chen S, Sims G, Chen X, Gu Y, Chen S, Lipsky P . Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007; 179(3):1634-47. DOI: 10.4049/jimmunol.179.3.1634. View

14.

Ravani P, Malberti F, Tripepi G, Pecchini P, Cutrupi S, Pizzini P . Vitamin D levels and patient outcome in chronic kidney disease. Kidney Int. 2008; 75(1):88-95. DOI: 10.1038/ki.2008.501. View

15.

Green J, Robinson D, Wilson G, Simpson R, Westfall M . Calcitriol modulation of cardiac contractile performance via protein kinase C. J Mol Cell Cardiol. 2006; 41(2):350-9. DOI: 10.1016/j.yjmcc.2006.05.019. View

16.

Kuo T, Yang D, Lin W, Tseng C, Chen J, Ho C . Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease. Int J Med Sci. 2015; 12(7):530-7. PMC: 4502056. DOI: 10.7150/ijms.12164. View

17.

Nibbelink K, Tishkoff D, Hershey S, Rahman A, Simpson R . 1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte. J Steroid Biochem Mol Biol. 2007; 103(3-5):533-7. PMC: 1890037. DOI: 10.1016/j.jsbmb.2006.12.099. View

18.

Santoro D, Caccamo D, Lucisano S, Buemi M, Sebekova K, Teta D . Interplay of vitamin D, erythropoiesis, and the renin-angiotensin system. Biomed Res Int. 2015; 2015:145828. PMC: 4427087. DOI: 10.1155/2015/145828. View

19.

Thadhani R, Appelbaum E, Pritchett Y, Chang Y, Wenger J, Tamez H . Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial. JAMA. 2012; 307(7):674-84. DOI: 10.1001/jama.2012.120. View

20.

Park C, Oh Y, Shin Y, Kim C, Kim Y, Kim S . Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism. Am J Kidney Dis. 1999; 33(1):73-81. DOI: 10.1016/s0272-6386(99)70260-x. View