Understanding and Overcoming Aminoglycoside Resistance Caused by N-6'-acetyltransferase

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2016 Dec 27

PMID 28018574

Citations 17

Authors

Kenward Vong

Karine Auclair

Affiliations

Soon will be listed here.

Abstract

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however menacing to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6'--acetyltransferase (AAC(6')).

Citing Articles

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Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation.

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El-Khoury C, Mansour E, Yuliandra Y, Lai F, Hawkins B, Du J RSC Med Chem. 2022; 13(11):1276-1299.

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