The Association Between Altered Lipid Profile and Suicide Attempt Among Tunisian Patients with Schizophrenia

Overview

Journal Ann Gen Psychiatry

Publisher Biomed Central

Specialty Psychiatry

Date 2016 Dec 27

PMID 28018476

Citations 6

Authors

Rym Mensi

Amal Messaoud

Ahmed Mhallah

Islem Azizi

Walid Haj Salah

Wahiba Douki

Mohamed Fadhel Najjar

Lotfi Gaha

Affiliations

Soon will be listed here.

Abstract

Background: There have been many studies on psychiatric disorders, but very little is known about the biology of suicide with schizophrenia. In the present study, we are looking for a possible connection between altered lipid profile and suicidal behavior in schizophrenic Tunisian patients.

Methods: Assay of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and triglycerides (TG) has been done for 126 schizophrenic patients with and without suicide attempts and 131 healthy controls recruited in the University Hospital of Monastir.

Results: TC and LDL-c levels were significantly higher in schizophrenic patients compared to controls. TC was significantly lower in schizophrenic patients with suicide attempt compared to those without suicide attempt. Depending to the sonority of suicide attempt, TC was significantly lower in patients with recent suicide attempt compared to those with lifetime suicide attempt and without suicide attempt ( < 0.001), and no significant differences between TG, LDL-c, and HDL-c were noted.

Conclusions: Results of this study showed that TC levels in schizophrenic patients after a recent suicide attempt are significantly lower than in patients without suicide attempt and with lifetime suicide attempts. TC can be one of biological markers defined suicidal risk for schizophrenic patients.

Citing Articles

Evaluation of mRNA expression level of the ATP synthase membrane subunit c locus 1 () gene in patients with schizophrenia.

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Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis.

Vasupanrajit A, Jirakran K, Tunvirachaisakul C, Solmi M, Maes M Mol Psychiatry. 2022; 27(3):1350-1361.

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Brain-Specific Oxysterols and Risk of Schizophrenia in Clinical High-Risk Subjects and Patients With Schizophrenia.

Sun Z, Zhao L, Bo Q, Mao Z, He Y, Jiang T Front Psychiatry. 2021; 12:711734.

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How do lipids influence risk of violence, self-harm and suicidality in people with psychosis? A systematic review.

Sen P, Adewusi D, Blakemore A, Kumari V Aust N Z J Psychiatry. 2021; 56(5):451-488.

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Lipids and Suicide Risk.

Sublette M Curr Top Behav Neurosci. 2020; 46:155-177.

PMID: 32840861 DOI: 10.1007/7854_2020_163.

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