Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by A

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2016 Dec 27

PMID 28018474

Citations 3

Authors

Yu Cao

Xingxing Jia

Yun Wei

Meixia Liu

Jiangang Liu

Hao Li

Affiliations

Soon will be listed here.

Abstract

. Huannao Yicong Decoction (HYD, ) has been shown to improve the learning and memory capabilities of Alzheimer's disease (AD) subjects. However, the underlying mechanism remains to be determined. . Sixty Sprague-Dawley rats were divided equally and randomly into five different groups including control, positive control, and HYD granules of low dose, medium dose, and high dose by daily gavage. The sham-treated rats were also given the same volume of sterile water by gavage. Twelve SD rats were treated with the same amount of physiological saline. Twelve weeks later, learning and memory capabilities, A content of the right brain and the expression of glycogen synthase kinase-3 (GSK-3), total tau protein kinase (TTBK1), and cyclin-dependent kinase-5 (CDK-5) were tested. . Our results showed that high dose HYD treatment significantly improved the learning and memory capability of the AD rats and decreased the expression of TTBK1, GSK-3, and CDK-5 in the hippocampal CA1 region. . HYD treatment for 12 weeks significantly improved spatial learning and memory and effectively inhibited A deposition, likely via reducing tau protein kinase expression and thus tau hyperphosphorylation and inflammatory injury. Taken together, these results suggest that HYD could be an effective treatment for AD.

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References

Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C . Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. PLoS Genet. 2010; 6(9):e1001087. PMC: 2932684. DOI: 10.1371/journal.pgen.1001087. View

Durairajan S, Liu L, Lu J, Chen L, Yuan Q, Chung S . Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. Neurobiol Aging. 2012; 33(12):2903-19. DOI: 10.1016/j.neurobiolaging.2012.02.016. View

Chabrier M, Blurton-Jones M, Agazaryan A, Nerhus J, Martinez-Coria H, LaFerla F . Soluble aβ promotes wild-type tau pathology in vivo. J Neurosci. 2012; 32(48):17345-50. PMC: 3586232. DOI: 10.1523/JNEUROSCI.0172-12.2012. View

Wong B, Hung Y, Bush A, Duce J . Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology. Front Aging Neurosci. 2014; 6:91. PMC: 4030154. DOI: 10.3389/fnagi.2014.00091. View

Hardy J, Selkoe D . The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002; 297(5580):353-6. DOI: 10.1126/science.1072994. View

Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M . Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway. J Biol Chem. 2012; 287(42):35222-35233. PMC: 3471719. DOI: 10.1074/jbc.M112.348300. View

Li R, Xu D, Ma T . Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience. 2015; 294:14-20. DOI: 10.1016/j.neuroscience.2015.03.005. View

Vijayapandi P, Annabathina V, SivaNagaSrikanth B, Manjunath V, Boggavarapu P, Mohammed P A . In vitro anticholinergic and antihistaminic activities of Acorus calamus Linn. leaves extracts. Afr J Tradit Complement Altern Med. 2013; 10(1):95-101. PMC: 3746362. View

Zhu F, Qian C . Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease. BMC Neurosci. 2006; 7:78. PMC: 1693919. DOI: 10.1186/1471-2202-7-78. View

10.

Majd S, Power J, Grantham H . Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways. BMC Neurosci. 2015; 16:69. PMC: 4619058. DOI: 10.1186/s12868-015-0211-1. View

11.

Morris M, Maeda S, Vossel K, Mucke L . The many faces of tau. Neuron. 2011; 70(3):410-26. PMC: 3319390. DOI: 10.1016/j.neuron.2011.04.009. View

12.

Lebel M, Patenaude C, Allyson J, Massicotte G, Cyr M . Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways. Neuropharmacology. 2009; 57(4):392-402. DOI: 10.1016/j.neuropharm.2009.06.041. View

13.

Liu T, Jin H, Sun Q, Xu J, Hu H . Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity. Brain Res. 2010; 1347:149-60. DOI: 10.1016/j.brainres.2010.05.079. View

14.

Gao C, Holscher C, Liu Y, Li L . GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease. Rev Neurosci. 2012; 23(1):1-11. DOI: 10.1515/rns.2011.061. View

15.

Gassowska M, Czapski G, Pajak B, Cieslik M, Lenkiewicz A, Adamczyk A . Extracellular α-synuclein leads to microtubule destabilization via GSK-3β-dependent Tau phosphorylation in PC12 cells. PLoS One. 2014; 9(4):e94259. PMC: 3983155. DOI: 10.1371/journal.pone.0094259. View

16.

Oddo S, Billings L, Kesslak J, Cribbs D, LaFerla F . Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron. 2004; 43(3):321-32. DOI: 10.1016/j.neuron.2004.07.003. View

17.

Devanand D, Lee S, Manly J, Andrews H, Schupf N, Doty R . Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community. Neurology. 2014; 84(2):182-9. PMC: 4336090. DOI: 10.1212/WNL.0000000000001132. View

18.

Hernandez-Perez J, Gutierrez-Guzman B, Lopez-Vazquez M, Olvera-Cortes M . Supramammillary serotonin reduction alters place learning and concomitant hippocampal, septal, and supramammillar theta activity in a Morris water maze. Front Pharmacol. 2015; 6:250. PMC: 4625187. DOI: 10.3389/fphar.2015.00250. View

19.

Li H, Yao M, Zhao W, Guan J, Cai L, Cui L . [A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment]. Zhong Xi Yi Jie He Xue Bao. 2008; 6(1):25-31. DOI: 10.3736/jcim20080106. View

20.

Jayant S, Sharma B, Bansal R, Sharma B . Pharmacological benefits of selective modulation of cannabinoid receptor type 2 (CB2) in experimental Alzheimer's disease. Pharmacol Biochem Behav. 2015; 140:39-50. DOI: 10.1016/j.pbb.2015.11.006. View