Watching Real-time Endocytosis in Living Cells
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
The precise sequence of events promoting clathrin-coated vesicle assembly is still debated. In this issue, Kadlecova et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608071) test structural models using quantitative microscopy in living cells to investigate the hierarchy and temporal importance of molecular events required for clathrin-coated pit initiation.
References
1.
Owen D, Evans P
. A structural explanation for the recognition of tyrosine-based endocytotic signals. Science. 1998; 282(5392):1327-32.
PMC: 5600252.
DOI: 10.1126/science.282.5392.1327.
View
2.
Hollopeter G, Lange J, Zhang Y, Vu T, Gu M, Ailion M
. The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex. Elife. 2014; 3.
PMC: 4215536.
DOI: 10.7554/eLife.03648.
View
3.
Dannhauser P, Ungewickell E
. Reconstitution of clathrin-coated bud and vesicle formation with minimal components. Nat Cell Biol. 2012; 14(6):634-9.
DOI: 10.1038/ncb2478.
View
4.
ter Haar E, Harrison S, Kirchhausen T
. Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proc Natl Acad Sci U S A. 2000; 97(3):1096-100.
PMC: 15533.
DOI: 10.1073/pnas.97.3.1096.
View
5.
Ma L, Umasankar P, Wrobel A, Lymar A, McCoy A, Holkar S
. Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding. Dev Cell. 2016; 37(5):428-43.
PMC: 4921775.
DOI: 10.1016/j.devcel.2016.05.003.
View