SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Dec 23

PMID 28006821

Citations 8

Authors

Antentor Othrell Hinton Jr

Yongjie Yang

Ann P Quick

Pingwen Xu

Chitra L Reddy

Xiaofeng Yan

Corey L Reynolds

Qingchun Tong

Liangru Zhu

Jianming Xu

Xander H T Wehrens

Yong Xu

Anilkumar K Reddy

Affiliations

Soon will be listed here.

Abstract

Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development of hypertension. However, there is no functional evidence linking steroid receptor coactivator-1 to the regulation of blood pressure. We used immunohistochemistry to map the expression of steroid receptor coactivator-1 protein in mouse brain, especially in regions implicated in the regulation of blood pressure. Steroid receptor coactivator-1 protein was found in central amygdala, medial amygdala, supraoptic nucleus, arcuate nucleus, ventromedial, dorsomedial, paraventricular hypothalamus, and nucleus of the solitary tract. To determine the effects of steroid receptor coactivator-1 protein on cardiovascular system we measured blood pressures, blood flow velocities, echocardiographic parameters, and aortic input impedance in female steroid receptor coactivator-1 knockout mice and their wild type littermates. Steroid receptor coactivator-1 knockout mice had higher blood pressures and increased aortic stiffness when compared to female wild type littermates. Additionally, the hearts of steroid receptor coactivator-1 knockout mice seem to consume higher energy as evidenced by increased impedance and higher heart rate pressure product when compared to female wild type littermates. Our results demonstrate that steroid receptor coactivator-1 may be functionally involved in the regulation of blood pressure and aortic stiffness through the regulation of sympathetic activation in various neuronal populations.

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