Tumour Microenvironment Factors Shaping the Cancer Metabolism Landscape

Overview

Journal Br J Cancer

Specialty Oncology

Date 2016 Dec 23

PMID 28006817

Citations 65

Authors

Dimitrios Anastasiou

Affiliations

Soon will be listed here.

Abstract

Cancer cells exhibit metabolic alterations that distinguish them from healthy tissues and make their metabolic processes susceptible to pharmacological targeting. Although typical cell-autonomous features of cancer metabolism have been emerging, it is increasingly appreciated that extrinsic factors also influence the metabolic properties of tumours. This review highlights evidence from the recent literature to discuss how conditions within the tumour microenvironment shape the metabolic character of tumours.

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References

Schug Z, Peck B, Jones D, Zhang Q, Grosskurth S, Alam I . Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell. 2015; 27(1):57-71. PMC: 4297291. DOI: 10.1016/j.ccell.2014.12.002. View

Padanad M, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M . Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Rep. 2016; 16(6):1614-1628. PMC: 4981512. DOI: 10.1016/j.celrep.2016.07.009. View

Lieberman B, Ploessl K, Wang L, Qu W, Zha Z, Wise D . PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine. J Nucl Med. 2011; 52(12):1947-55. DOI: 10.2967/jnumed.111.093815. View

Gomes A, Teijeiro A, Buren S, Tummala K, Yilmaz M, Waisman A . Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma. Cancer Cell. 2016; 30(1):161-175. DOI: 10.1016/j.ccell.2016.05.020. View

Yuneva M, Fan T, Allen T, Higashi R, Ferraris D, Tsukamoto T . The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab. 2012; 15(2):157-70. PMC: 3282107. DOI: 10.1016/j.cmet.2011.12.015. View

Pearce E, Poffenberger M, Chang C, Jones R . Fueling immunity: insights into metabolism and lymphocyte function. Science. 2013; 342(6155):1242454. PMC: 4486656. DOI: 10.1126/science.1242454. View

Tardito S, Oudin A, Ahmed S, Fack F, Keunen O, Zheng L . Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nat Cell Biol. 2015; 17(12):1556-68. PMC: 4663685. DOI: 10.1038/ncb3272. View

Fan J, Ye J, Kamphorst J, Shlomi T, Thompson C, Rabinowitz J . Quantitative flux analysis reveals folate-dependent NADPH production. Nature. 2014; 510(7504):298-302. PMC: 4104482. DOI: 10.1038/nature13236. View

Fan J, Kamphorst J, Mathew R, Chung M, White E, Shlomi T . Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol. 2013; 9:712. PMC: 3882799. DOI: 10.1038/msb.2013.65. View

10.

Opitz C, Litzenburger U, Sahm F, Ott M, Tritschler I, Trump S . An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011; 478(7368):197-203. DOI: 10.1038/nature10491. View

11.

Galluzzi L, Kepp O, Vander Heiden M, Kroemer G . Metabolic targets for cancer therapy. Nat Rev Drug Discov. 2013; 12(11):829-46. DOI: 10.1038/nrd4145. View

12.

Kamphorst J, Nofal M, Commisso C, Hackett S, Lu W, Grabocka E . Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 2015; 75(3):544-53. PMC: 4316379. DOI: 10.1158/0008-5472.CAN-14-2211. View

13.

Overholtzer M, Mailleux A, Mouneimne G, Normand G, Schnitt S, King R . A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell. 2007; 131(5):966-79. DOI: 10.1016/j.cell.2007.10.040. View

14.

De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong B, Cantelmo A . Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013; 154(3):651-63. DOI: 10.1016/j.cell.2013.06.037. View

15.

DSouza-Schorey C, Clancy J . Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev. 2012; 26(12):1287-99. PMC: 3387656. DOI: 10.1101/gad.192351.112. View

16.

Chaudhri V, Salzler G, Dick S, Buckman M, Sordella R, Karoly E . Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor. Mol Cancer Res. 2013; 11(6):579-92. PMC: 3686965. DOI: 10.1158/1541-7786.MCR-12-0437-T. View

17.

Cheng T, Sudderth J, Yang C, Mullen A, Jin E, Mates J . Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. Proc Natl Acad Sci U S A. 2011; 108(21):8674-9. PMC: 3102381. DOI: 10.1073/pnas.1016627108. View

18.

Schafer Z, Grassian A, Song L, Jiang Z, Gerhart-Hines Z, Irie H . Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009; 461(7260):109-13. PMC: 2931797. DOI: 10.1038/nature08268. View

19.

Junttila M, de Sauvage F . Influence of tumour micro-environment heterogeneity on therapeutic response. Nature. 2013; 501(7467):346-54. DOI: 10.1038/nature12626. View

20.

Chandel N, Maltepe E, GOLDWASSER E, Mathieu C, Simon M, Schumacker P . Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A. 1998; 95(20):11715-20. PMC: 21706. DOI: 10.1073/pnas.95.20.11715. View