Comparative Study of the Efficacy and Safety of Paracetamol, Ibuprofen, and Indomethacin in Closure of Patent Ductus Arteriosus in Preterm Neonates

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2016 Dec 23

PMID 28004188

Citations 61

Authors

Abd El-Rahman El-Mashad

Heba El-Mahdy

Doaa El Amrousy

Marwa Elgendy

Affiliations

Soon will be listed here.

Abstract

Conclusion: Paracetamol is as effective as indomethacin and ibuprofen in closure of PDA in preterm neonates and has less side effects mainly on renal function, platelet count, and GIT bleeding. What is Known: • Hemodynamically significant patent ductus arteriosus has many complications for preterm and low birth weight neonates and better to be closed. Many drugs were used for medical closure of PDA e.g. indomethacin, ibuprofen and recently paracetamol. Many studies compare safety and efficacy of paracetamol with either indomethacin or ibuprofen. What is New: • It is the first large study that compares the efficacy and side effects of the three drugs in one study.

Citing Articles

Response of the ductus arteriosus to acetaminophen or indomethacin in extremely low birth weight infants.

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Use of NSAIDs and acetaminophen and risk of spontaneous intestinal perforations in premature infants: a systematic review and meta-analysis.

Hudson J, Shabbir W, Hayawi L, Chan M, Barrowman N, Sikora L Front Pediatr. 2024; 12:1450121.

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Perinatal Factors Associated with Successful Pharmacologic Closure of the Patent Ductus Arteriosus in Premature Infants.

Sharma P, Gearhart A, Beam K, Spyropoulos F, Powell A, Beam A Pediatr Cardiol. 2024; .

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A comparison of different dosing regimen of intravenous paracetamol for hemodynamically significant patent ductus arteriosus closure in premature neonates <32 weeks: a prospective observational study.

Goyal N, Haribalakrishna A, Krishnamurthy B J Perinatol. 2024; 44(10):1463-1469.

PMID: 38622217 DOI: 10.1038/s41372-024-01966-8.

Treatment of Patent Ductus Arteriosus in Premature Infants: Intravenous Paracetamol or Oral Ibuprofen?.

Taleghani N, Hamrahi B, Falahi M, Nazar E, Palizban F, Naseh A Arch Iran Med. 2024; 26(6):330-337.

PMID: 38310434 PMC: 10685834. DOI: 10.34172/aim.2023.50.

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