Endocan and the Respiratory System: a Review

Overview

Journal Int J Chron Obstruct Pulmon Dis

Publisher Dove Medical Press

Specialty Pulmonary Medicine

Date 2016 Dec 23

PMID 28003744

Citations 18

Authors

Maria Kechagia

Ioannis Papassotiriou

Konstantinos I Gourgoulianis

Affiliations

Soon will be listed here.

Abstract

Endocan, formerly called endothelial cell-specific molecule 1, is an endothelial cell-associated proteoglycan that is preferentially expressed by renal and pulmonary endothelium. It is upregulated by proangiogenic molecules as well as by pro-inflammatory cytokines, and since it reflects endothelial activation and dysfunction, it is regarded as a novel tissue and blood-based relevant biomarker. As such, it is increasingly being researched and evaluated in a wide spectrum of healthy and disease pathophysiological processes. Here, we review the present scientific knowledge on endocan, with emphasis on the evidence that underlines its possible clinical value as a prognostic marker in several malignant, inflammatory and obstructive disorders of the respiratory system.

Citing Articles

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Endocan, a novel glycoprotein with multiple biological activities, may play important roles in neurological diseases.

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