Expression and Clinical Significance of C14orf166 in Esophageal Squamous Cell Carcinoma

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2016 Dec 22

PMID 28000881

Citations 1

Authors

Yan-Wu Zhou

Rong Li

Chao-Jun Duan

Yang Gao

Yuan-Da Cheng

Zhi-Wei He

Jun-Xian Zeng

Chun-Fang Zhang

Affiliations

Soon will be listed here.

Abstract

C14orf166, a 28 kD protein regulating RNA transcription and translation, may serve a critical role in oncogenesis. The aim of the current study was to explore the association between C14orf166 expression and esophageal squamous cell carcinoma (ESCC) and to draw attention to the association between C14orf166 and the initiation, progression and prognosis of ESCC. C14orf166 expression in ESCC and paired normal tissues was detected by immunohistochemical staining, western blotting and reverse transcription‑quantitative polymerase chain reaction, and the association between C14orf166 expression and clinicopathological characters of ESCC was analyzed. Survival analysis was used to assess the prognostic significance of C14orf166 and it was observed that C14orf166 expression was higher in the ESCC tissues when compared with adjacent non‑cancerous tissues at protein (P<0.001) and mRNA levels (P<0.001). There was a significant difference in T stage, lymph node metastasis and TNM stage in patients categorized according to different C14orf166 expression levels. The overexpression of C14orf166 was associated with a shorter overall survival and disease‑free survival, and multivariate analysis indicated that C14orf166 was an independent prognostic indicator. The present study indicates that the expression of C14orf166 is elevated in ESCC, and is potentially a valuable prognostic predictor for ESCC.

Citing Articles

Overexpressed C14orf166 associates with disease progression and poor prognosis in non-small-cell lung cancer.

Zhou Y, Li R, Duan C, Gao Y, Cheng Y, Zhang C Biosci Rep. 2018; 38(5).

PMID: 30126850 PMC: 6137245. DOI: 10.1042/BSR20180479.

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