Vulnerable Atherosclerotic Plaque Detection by Resonance Raman Spectroscopy

Overview

Journal J Biomed Opt

Specialties Biomedical Engineering
Ophthalmology

Date 2016 Dec 22

PMID 27999865

Citations 6

Authors

Cheng-Hui Liu

Susie Boydston-White

Arel Weisberg

Wubao Wang

Laura A Sordillo

Adler Perotte

Vincent P Tomaselli

Peter P Sordillo

Zhe Pei

Lingyan Shi

Robert R Alfano

Affiliations

Soon will be listed here.

Abstract

A clear correlation has been observed between the resonance Raman (RR) spectra of plaques in the aortic tunica intimal wall of a human corpse and three states of plaque evolution: fibrolipid plaques, calcified and ossified plaques, and vulnerable atherosclerotic plaques (VPs). These three states of atherosclerotic plaque lesions demonstrated unique RR molecular fingerprints from key molecules, rendering their spectra unique with respect to one another. The vibrational modes of lipids, cholesterol, carotenoids, tryptophan and heme proteins, the amide I, II, III bands, and methyl/methylene groups from the intrinsic atherosclerotic VPs in tissues were studied. The salient outcome of the investigation was demonstrating the correlation between RR measurements of VPs and the thickness measurements of fibrous caps on VPs using standard histopathology methods, an important metric in evaluating the stability of a VP. The RR results show that VPs undergo a structural change when their caps thin to 66 ?? ? m , very close to the 65 - ? m empirical medical definition of a thin cap fibroatheroma plaque, the most unstable type of VP.

Citing Articles

Physicochemical understanding of biomineralization by molecular vibrational spectroscopy: From mechanism to nature.

Liu H, Jiang H, Liu X, Wang X Exploration (Beijing). 2024; 3(6):20230033.

PMID: 38264681 PMC: 10742219. DOI: 10.1002/EXP.20230033.

Vibrational spectroscopy identifies myocardial chemical modifications in heart failure with preserved ejection fraction.

Pioppi L, Parvan R, Samrend A, Silva G, Paolantoni M, Sassi P J Transl Med. 2023; 21(1):617.

PMID: 37697391 PMC: 10496315. DOI: 10.1186/s12967-023-04465-0.

A Handheld Visible Resonance Raman Analyzer Used in Intraoperative Detection of Human Glioma.

Zhang L, Zhou Y, Wu B, Zhang S, Zhu K, Liu C Cancers (Basel). 2023; 15(6).

PMID: 36980638 PMC: 10046110. DOI: 10.3390/cancers15061752.

Distinguishing metastatic triple-negative breast cancer from nonmetastatic breast cancer using second harmonic generation imaging and resonance Raman spectroscopy.

Bendau E, Smith J, Zhang L, Ackerstaff E, Kruchevsky N, Wu B J Biophotonics. 2020; 13(7):e202000005.

PMID: 32219996 PMC: 7433748. DOI: 10.1002/jbio.202000005.

Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy.

Zhou Y, Liu C, Wu B, Yu X, Cheng G, Zhu K J Biomed Opt. 2019; 24(9):1-12.

PMID: 31512439 PMC: 6997631. DOI: 10.1117/1.JBO.24.9.095001.

References

Wang L, Ho P, Liu C, Zhang G, Alfano R . Ballistic 2-d imaging through scattering walls using an ultrafast optical kerr gate. Science. 1991; 253(5021):769-71. DOI: 10.1126/science.253.5021.769. View

Hofbauer L, Brueck C, Shanahan C, Schoppet M, Dobnig H . Vascular calcification and osteoporosis--from clinical observation towards molecular understanding. Osteoporos Int. 2006; 18(3):251-9. DOI: 10.1007/s00198-006-0282-z. View

Zhou Y, Liu C, Sun Y, Pu Y, Boydston-White S, Liu Y . Human brain cancer studied by resonance Raman spectroscopy. J Biomed Opt. 2012; 17(11):116021. PMC: 3499405. DOI: 10.1117/1.JBO.17.11.116021. View

Motz J, Fitzmaurice M, Miller A, Gandhi S, Haka A, Galindo L . In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque. J Biomed Opt. 2006; 11(2):021003. DOI: 10.1117/1.2190967. View

Baraga J, Feld M, Rava R . In situ optical histochemistry of human artery using near infrared Fourier transform Raman spectroscopy. Proc Natl Acad Sci U S A. 1992; 89(8):3473-7. PMC: 48890. DOI: 10.1073/pnas.89.8.3473. View

Burke A, Farb A, Malcom G, Liang Y, Smialek J, Virmani R . Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997; 336(18):1276-82. DOI: 10.1056/NEJM199705013361802. View

Clarke R, Hanlon E, Isner J, Brody H . Laser Raman spectroscopy of calcified atherosclerotic lesions in cardiovascular tissue. Appl Opt. 2010; 26(16):3175-7. DOI: 10.1364/AO.26.003175. View

Mohler 3rd E, Gannon F, Reynolds C, Zimmerman R, Keane M, Kaplan F . Bone formation and inflammation in cardiac valves. Circulation. 2001; 103(11):1522-8. DOI: 10.1161/01.cir.103.11.1522. View

MacNeill B, Lowe H, Takano M, Fuster V, Jang I . Intravascular modalities for detection of vulnerable plaque: current status. Arterioscler Thromb Vasc Biol. 2003; 23(8):1333-42. DOI: 10.1161/01.ATV.0000080948.08888.BF. View

10.

Ji M, Orringer D, Freudiger C, Ramkissoon S, Liu X, Lau D . Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med. 2013; 5(201):201ra119. PMC: 3806096. DOI: 10.1126/scitranslmed.3005954. View

11.

Hayden M, Tyagi S, Kolb L, Sowers J, Khanna R . Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. Cardiovasc Diabetol. 2005; 4:4. PMC: 1079905. DOI: 10.1186/1475-2840-4-4. View

12.

Fazio G, Redberg R, Winslow T, Schiller N . Transesophageal echocardiographically detected atherosclerotic aortic plaque is a marker for coronary artery disease. J Am Coll Cardiol. 1993; 21(1):144-50. DOI: 10.1016/0735-1097(93)90729-k. View

13.

Liu C, Zhou Y, Sun Y, Li J, Zhou L, Boydston-White S . Resonance Raman and Raman spectroscopy for breast cancer detection. Technol Cancer Res Treat. 2013; 12(4):371-82. DOI: 10.7785/tcrt.2012.500325. View

14.

Nogueira G, Silveira L, Martin A, Zangaro R, Pacheco M, Chavantes M . Raman spectroscopy study of atherosclerosis in human carotid artery. J Biomed Opt. 2005; 10(3):031117. DOI: 10.1117/1.1908129. View

15.

Romer T, Brennan 3rd J, Fitzmaurice M, Feldstein M, Deinum G, Myles J . Histopathology of human coronary atherosclerosis by quantifying its chemical composition with Raman spectroscopy. Circulation. 1998; 97(9):878-85. DOI: 10.1161/01.cir.97.9.878. View

16.

Jermyn M, Mok K, Mercier J, Desroches J, Pichette J, Saint-Arnaud K . Intraoperative brain cancer detection with Raman spectroscopy in humans. Sci Transl Med. 2015; 7(274):274ra19. DOI: 10.1126/scitranslmed.aaa2384. View

17.

van de Poll S, Kastelijn K, Bakker Schut T, Strijder C, Pasterkamp G, Puppels G . On-line detection of cholesterol and calcification by catheter based Raman spectroscopy in human atherosclerotic plaque ex vivo. Heart. 2003; 89(9):1078-82. PMC: 1767825. DOI: 10.1136/heart.89.9.1078. View

18.

Adar F, Erecinska M . Photoreductive titration of the resonance Raman spectra of cytochrome oxidase in whole mitochondria. Biochemistry. 1979; 18(9):1825-9. DOI: 10.1021/bi00576a030. View

19.

Mermut O, York R, Phillips D, McCrea K, Ward R, Somorjai G . Directions in peptide interfacial science. Biointerphases. 2010; 1(2):P5-11. DOI: 10.1116/1.2194033. View

20.

van der Wal A, Becker A . Atherosclerotic plaque rupture--pathologic basis of plaque stability and instability. Cardiovasc Res. 1999; 41(2):334-44. DOI: 10.1016/s0008-6363(98)00276-4. View