Familial Creutzfeldt-Jakob Disease Cluster Among an African American Family
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Abstract
Familial Creutzfeldt-Jakob disease (fCJD) results from inheritance of mutations in the prion protein gene. Confirming fCJD diagnosis is essential for informing persons of their potential hereditary risk and for genetic counseling to support personal decisions for genetic testing and family planning. We describe a case of fCJD that was linked to a large cluster of African Americans with fCJD identified through a public health investigation, including 8 confirmed cases and 13 suspected cases involving 7 generations in 1 family. Genetic counseling is an important component of fCJD management for families coping with genetic prion diseases.
References
1.
Holman R, Belay E, Christensen K, Maddox R, Minino A, Folkema A
. Human prion diseases in the United States. PLoS One. 2010; 5(1):e8521.
PMC: 2797136.
DOI: 10.1371/journal.pone.0008521.
View
2.
Belay E, Schonberger L
. The public health impact of prion diseases. Annu Rev Public Health. 2005; 26:191-212.
DOI: 10.1146/annurev.publhealth.26.021304.144536.
View
3.
Puoti G, Bizzi A, Forloni G, Safar J, Tagliavini F, Gambetti P
. Sporadic human prion diseases: molecular insights and diagnosis. Lancet Neurol. 2012; 11(7):618-28.
DOI: 10.1016/S1474-4422(12)70063-7.
View
4.
Damewood M
. Ethical implications of a new application of preimplantation diagnosis. JAMA. 2001; 285(24):3143-4.
DOI: 10.1001/jama.285.24.3143.
View
5.
Goldman J, Miller B, Safar J, de Tourreil S, Martindale J, Prusiner S
. When sporadic disease is not sporadic: the potential for genetic etiology. Arch Neurol. 2004; 61(2):213-6.
DOI: 10.1001/archneur.61.2.213.
View