Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

Overview

Journal Balkan Med J

Publisher Galenos Publishing House

Specialty General Medicine

Date 2016 Dec 21

PMID 27994913

Citations 3

Authors

Cevik Gurel

Ahmet Inanir

Ayse Feyda Nursal

Akin Tekcan

Aydin Rustemoglu

Serbulent Yigit

Affiliations

Soon will be listed here.

Abstract

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory factor is a regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play a role in the progression of several inflammatory disorders.

Aims: To investigate the relationship between the single-nucleotide polymorphism (SNP) and AS.

Study Design: Cross-sectional study.

Methods: In this study, a total of 161 AS and 194 normal controls were recruited. The MIF gene -173 G/C SNP was analyzed by polymerase chain reaction using the restriction fragment length polymorphism method.

Results: There was no significant difference between groups in terms of genotype distribution (p>0.05). When wild-type G/G and G/C+C/C genotypes are compared in terms of clinical characteristics, there is a significant difference between the average age and the duration of disease in AS patients (p<0.05).

Conclusion: No significant relationship between AS disease and polymorphism was found. polymorphism (C allele) may affect the time of onset and the duration of disease in AS patients.

Citing Articles

Association of Macrophage Migration Inhibitory Factor Gene -173 G/C Polymorphism (rs755622) with Familial Mediterranean Fever in Children.

Cakan N, Yilmaz R, Karaaslan E, Ates O J Pediatr Genet. 2022; 11(2):91-98.

PMID: 35769958 PMC: 9236749. DOI: 10.1055/s-0040-1719053.

Immunopathophysiology of Juvenile Spondyloarthritis (jSpA): The "Out of the Box" View on Epigenetics, Neuroendocrine Pathways and Role of the Macrophage Migration Inhibitory Factor (MIF).

Harjacek M Front Med (Lausanne). 2021; 8:700982.

PMID: 34692718 PMC: 8526544. DOI: 10.3389/fmed.2021.700982.

The Role of MIF-173G/C Gene Polymorphism in the Susceptibility of Autoimmune Diseases.

Du X, Li R, Song S, Ma L, Xue H Mediators Inflamm. 2020; 2020:7825072.

PMID: 32410863 PMC: 7204238. DOI: 10.1155/2020/7825072.

References

Park S, Choe J, Kim S, Lee H, Castrejon I, Pincus T . Routine Assessment of Patient Index Data (RAPID3) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Scores Yield Similar Information in 85 Korean Patients With Ankylosing Spondylitis Seen in Usual Clinical Care. J Clin Rheumatol. 2015; 21(6):300-4. PMC: 4629489. DOI: 10.1097/RHU.0000000000000277. View

Nalbantoglu S, Tabel Y, Mir S, Berdeli A . Lack of association between macrophage migration inhibitory factor gene promoter (-173 G/C) polymorphism and childhood Henoch-Schönlein purpura in Turkish patients. Cytokine. 2013; 62(1):160-4. DOI: 10.1016/j.cyto.2013.02.024. View

Wang F, Huang X, Shen N, Leng L, Bucala R, Chen S . A genetic role for macrophage migration inhibitory factor (MIF) in adult-onset Still's disease. Arthritis Res Ther. 2013; 15(3):R65. PMC: 4060242. DOI: 10.1186/ar4239. View

Smith J . Update on ankylosing spondylitis: current concepts in pathogenesis. Curr Allergy Asthma Rep. 2014; 15(1):489. DOI: 10.1007/s11882-014-0489-6. View

Llamas-Covarrubias M, Valle Y, Bucala R, Navarro-Hernandez R, Palafox-Sanchez C, Padilla-Gutierrez J . Macrophage migration inhibitory factor (MIF): genetic evidence for participation in early onset and early stage rheumatoid arthritis. Cytokine. 2013; 61(3):759-65. PMC: 3683988. DOI: 10.1016/j.cyto.2012.12.032. View

Fei B, Lv H, Yang J, Ye Z . Association of MIF-173 gene polymorphism with inflammatory bowel disease in Chinese Han population. Cytokine. 2007; 41(1):44-7. DOI: 10.1016/j.cyto.2007.10.010. View

Liu R, Xu N, Wang X, Shen L, Zhao G, Zhang H . Influence of MIF, CD40, and CD226 polymorphisms on risk of rheumatoid arthritis. Mol Biol Rep. 2012; 39(6):6915-22. DOI: 10.1007/s11033-012-1518-y. View

De Benedetti F, Meazza C, Vivarelli M, Rossi F, Pistorio A, Lamb R . Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2003; 48(5):1398-407. DOI: 10.1002/art.10882. View

Gunal E, Sarvan F, Kamali S, Gul A, Inanc M, Carin M . Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey. Joint Bone Spine. 2008; 75(3):299-302. DOI: 10.1016/j.jbspin.2007.06.021. View

10.

Wu J, Ren X, Jin Y, Huang X, Zhang X, Bai J . Association of MIF promoter polymorphisms with childhood asthma in a northeastern Chinese population. Tissue Antigens. 2009; 73(4):302-6. DOI: 10.1111/j.1399-0039.2008.01206.x. View

11.

Renner P, Roger T, Calandra T . Macrophage migration inhibitory factor: gene polymorphisms and susceptibility to inflammatory diseases. Clin Infect Dis. 2005; 41 Suppl 7:S513-9. DOI: 10.1086/432009. View

12.

Donn R, Shelley E, Ollier W, Thomson W . A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2001; 44(8):1782-5. DOI: 10.1002/1529-0131(200108)44:8<1782::AID-ART314>3.0.CO;2-#. View

13.

Makhija R, Kingsnorth A, Demaine A . Gene polymorphisms of the macrophage migration inhibitory factor and acute pancreatitis. JOP. 2007; 8(3):289-95. View

14.

Barton A, Lamb R, Symmons D, Silman A, Thomson W, Worthington J . Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis. Genes Immun. 2003; 4(7):487-91. DOI: 10.1038/sj.gene.6364014. View

15.

Nohara H, Okayama N, Inoue N, Koike Y, Fujimura K, Suehiro Y . Association of the -173 G/C polymorphism of the macrophage migration inhibitory factor gene with ulcerative colitis. J Gastroenterol. 2004; 39(3):242-6. DOI: 10.1007/s00535-003-1284-7. View

16.

Daikh D, Chen P . Advances in managing ankylosing spondylitis. F1000Prime Rep. 2014; 6:78. PMC: 4166936. DOI: 10.12703/P6-78. View

17.

Kozaci L, Sari I, Alacacioglu A, Akar S, Akkoc N . Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor. Mod Rheumatol. 2009; 20(1):34-9. DOI: 10.1007/s10165-009-0230-9. View

18.

Donn R, Plant D, Jury F, Richards H, Worthington J, Ray D . Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis. J Invest Dermatol. 2004; 123(3):484-7. DOI: 10.1111/j.0022-202X.2004.23314.x. View

19.

Cinar M, Akar H, Yilmaz S, Simsek I, Karkucak M, Ilikci Sagkan R . A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population. Rheumatol Int. 2013; 33(11):2851-8. DOI: 10.1007/s00296-013-2824-y. View

20.

Przybylowska K, Mrowicki J, Sygut A, Narbutt P, Dziki L, Dziki A . Contribution of the -173 G/C polymorphism of macrophage migration inhibitory factor gene to the risk of inflammatory bowel diseases. Pol Przegl Chir. 2011; 83(2):76-80. DOI: 10.2478/v10035-011-0012-x. View