» Articles » PMID: 27994873

Submental Thyroid Ectopy Might Cause Subclinical Hypothyroidism in Early Childhood

Overview
Publisher Sage Publications
Specialty General Medicine
Date 2016 Dec 21
PMID 27994873
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: Thyroid ectopy is a rare condition resulting from abnormal embryologic development and migration of the gland. Sublingual is the most common thyroid ectopy; all other ectopic thyroid locations occur very rare. There are no reports in the literature that describe the clinical course of patients with congenital hypothyroidism due to thyroid ectopy.

Methods And Results: We present a child with congenital hypothyroidism detected on neonatal screening which had a subclinical course during follow-up. Scintigraphy revealed submental thyroid ectopy, a rare ectopic location and no orthotopic thyroid gland.

Conclusion: Our case is unique because of the rare ectopic thyroid location but also of the unexpected clinical course; however, further thyroid monitoring is required for the therapy adjustment and detection of any changes in the ectopic tissue.

Citing Articles

Submental Ectopic Thyroid in a Patient with an Orthotopic Thyroid Gland.

Mak C J Med Ultrasound. 2022; 30(3):229-232.

PMID: 36484044 PMC: 9724466. DOI: 10.4103/jmu.jmu_157_21.

References
1.
Olivieri A, Corbetta C, Weber G, Vigone M, Fazzini C, Medda E . Congenital hypothyroidism due to defects of thyroid development and mild increase of TSH at screening: data from the Italian National Registry of infants with congenital hypothyroidism. J Clin Endocrinol Metab. 2013; 98(4):1403-8. DOI: 10.1210/jc.2012-3273. View

2.
van Engelen K, Mommersteeg M, Baars M, Lam J, Ilgun A, van Trotsenburg A . The ambiguous role of NKX2-5 mutations in thyroid dysgenesis. PLoS One. 2013; 7(12):e52685. PMC: 3532205. DOI: 10.1371/journal.pone.0052685. View

3.
Romero-Rojas A, Bella-Cueto M, Meza-Cabrera I, Cabezuelo-Hernandez A, Garcia-Rojo D, Vargas-Uricoechea H . Ectopic thyroid tissue in the adrenal gland: a report of two cases with pathogenetic implications. Thyroid. 2013; 23(12):1644-50. PMC: 3868403. DOI: 10.1089/thy.2013.0063. View

4.
Guerrissi J . Follicular variant of papillary carcinoma in submandibular ectopic thyroid with no orthotopic thyroid gland. J Craniofac Surg. 2012; 23(1):138-9. DOI: 10.1097/SCS.0b013e3182413d87. View

5.
Corbetta C, Weber G, Cortinovis F, Calebiro D, Passoni A, Vigone M . A 7-year experience with low blood TSH cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (CH). Clin Endocrinol (Oxf). 2009; 71(5):739-45. DOI: 10.1111/j.1365-2265.2009.03568.x. View