Comparative Evaluation of Calcium Silicate-based Dentin Substitute (Biodentine) and Calcium Hydroxide (pulpdent) in the Formation of Reactive Dentin Bridge in Regenerative Pulpotomy of Vital Primary Teeth: Triple Blind, Randomized Clinical Trial

Overview

Journal Contemp Clin Dent

Specialty Dentistry

Date 2016 Dec 21

PMID 27994411

Citations 12

Authors

Navneet Grewal

Rubica Salhan

Nirapjeet Kaur

Hemal Bipin Patel

Affiliations

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Abstract

Background: Considering the biological concerns of calcium hydroxide (CH) as a pulpotomy agent, an alternative silicate based dentin substitute i.e. Biodentine (CaSiO) was evaluated clinically and radiographically.

Aims: To evaluate the effectiveness of dentin substitute (Biodentine) in regenerative pulpotomy of vital primary teeth that would giv a biological base to its use in forming reactive dentin bridge and overcoming the drawbacks of calcium hydroxide.

Material And Methods: Randomised clinical trial on 40 bilateral carious primary molars in 20 participant children (aged 5-10 years) was carried out by same operator using CaSiO(group-1) and CH (group-2) as vital pulpotomy agents. Blinded clinical and radiographic outcomes were observed at 3, 6 and 12 months interval.

Results: Clinical outcomes of both protocols were analysed using Pearson's chi-square test applied at < 0.05. Descriptive statistics were expressed as mean increase in dentin bridge formation in mms from two reference points in standardized radiographs using paired ''- test at baseline and 12 months and found to be statistically significant ( < 0.05) in group-1 when compared with group-2.

Conclusion: Group-1 revealed statistically favourable regenerative potential along with clinical success compared to group 2 thereby sharing both indications and mode of action with CH, but without its drawbacks of physical and clinical properties.

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References

El Karim I, McCrudden M, McGahon M, Curtis T, Jeanneau C, Giraud T . Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells. J Endod. 2016; 42(4):589-95. DOI: 10.1016/j.joen.2015.12.017. View

Ghoddusi J, Forghani M, Parisay I . New approaches in vital pulp therapy in permanent teeth. Iran Endod J. 2014; 9(1):15-22. PMC: 3881297. View

Nowicka A, Lipski M, Parafiniuk M, Sporniak-Tutak K, Lichota D, Kosierkiewicz A . Response of human dental pulp capped with biodentine and mineral trioxide aggregate. J Endod. 2013; 39(6):743-7. DOI: 10.1016/j.joen.2013.01.005. View

Koubi G, Colon P, Franquin J, Hartmann A, Richard G, Faure M . Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth - a prospective study. Clin Oral Investig. 2012; 17(1):243-9. PMC: 3536989. DOI: 10.1007/s00784-012-0701-9. View

Daltoe M, Paula-Silva F, Faccioli L, Gaton-Hernandez P, de Rossi A, Silva L . Expression of Mineralization Markers during Pulp Response to Biodentine and Mineral Trioxide Aggregate. J Endod. 2016; 42(4):596-603. DOI: 10.1016/j.joen.2015.12.018. View

Parirokh M, Torabinejad M . Mineral trioxide aggregate: a comprehensive literature review--Part III: Clinical applications, drawbacks, and mechanism of action. J Endod. 2010; 36(3):400-13. DOI: 10.1016/j.joen.2009.09.009. View

de Rossi A, Silva L, Gaton-Hernandez P, Sousa-Neto M, Nelson-Filho P, Silva R . Comparison of pulpal responses to pulpotomy and pulp capping with biodentine and mineral trioxide aggregate in dogs. J Endod. 2014; 40(9):1362-9. DOI: 10.1016/j.joen.2014.02.006. View

Camilleri J . Characterization and hydration kinetics of tricalcium silicate cement for use as a dental biomaterial. Dent Mater. 2011; 27(8):836-44. DOI: 10.1016/j.dental.2011.04.010. View

Lin P, Chen H, Wang Y, Tu Y . Primary molar pulpotomy: a systematic review and network meta-analysis. J Dent. 2014; 42(9):1060-77. DOI: 10.1016/j.jdent.2014.02.001. View

10.

Holan G, Eidelman E, Fuks A . Long-term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. Pediatr Dent. 2005; 27(2):129-36. View

11.

Rutherford B, Fitzgerald M . A new biological approach to vital pulp therapy. Crit Rev Oral Biol Med. 1995; 6(3):218-29. DOI: 10.1177/10454411950060030401. View

12.

Smith N, Seale N, Nunn M . Ferric sulfate pulpotomy in primary molars: a retrospective study. Pediatr Dent. 2000; 22(3):192-9. View

13.

Luo Z, Kohli M, Yu Q, Kim S, Qu T, He W . Biodentine induces human dental pulp stem cell differentiation through mitogen-activated protein kinase and calcium-/calmodulin-dependent protein kinase II pathways. J Endod. 2014; 40(7):937-42. DOI: 10.1016/j.joen.2013.11.022. View