Sterol Requirement of Mycoplasma Capricolum

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1978 Sep 1

PMID 279900

Citations 12

Authors

J M Odriozola

E Waitzkin

T L Smith

K Bloch

Affiliations

Soon will be listed here.

Abstract

Mycoplasmas require an external source of sterol for growth. For Mycoplasma capricolum this requirement is met not only by cholesterol but also by the methylcholestane derivatives lanosterol, cycloartenol, 4,4-dimethylcholesterol, and 4beta-methylcholestanol. Cholesteryl methyl ether and 3alpha-methylcholestanol serve equally well as sterol supplements. None of the growth-supporting sterol derivatives tested was metabolically modified. The unusual acceptance of diverse cholestane derivatives by a mycoplasma species contrasts with the structural attributes thought to be necessary for sterol function in eukaryotic membranes.

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