Histological Underpinnings of Grey Matter Changes in Fibromyalgia Investigated Using Multimodal Brain Imaging

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Dec 18

PMID 27986927

Citations 41

Authors

Florence B Pomares

Thomas Funck

Natasha A Feier

Steven Roy

Alexandre Daigle-Martel

Marta ceko

Sridar Narayanan

David Araujo

Alexander Thiel

Nikola Stikov

Mary-Ann Fitzcharles

Petra Schweinhardt

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Regional gray matter alterations in chronic pain, as detected with voxel-based morphometry of anatomical magnetic resonance images, are commonly interpreted to reflect neurodegeneration, but this assumption has not been tested. We found decreased gray matter in fibromyalgia to be associated with T1 relaxation times, a surrogate marker of water content, but not with GABA receptor concentration, a surrogate of neuronal integrity. In contrast, regional gray matter increases were partly explained by GABA receptor concentration, indicating some form of neuronal plasticity. The study emphasizes that voxel-based morphometry is an exploratory measure, demonstrating the need to investigate the histological origin of gray matter alterations for every distinct clinical entity, and advances the understanding of the neurobiology of chronic (widespread) pain.

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