Spatial Signalling Mediated by the Transforming Growth Factor-β Signalling Pathway During Tooth Formation

Overview

Journal Int J Oral Sci

Date 2016 Dec 17

PMID 27982023

Citations 3

Authors

Xin-Yu He

Ke Sun

Ruo-Shi Xu

Jia-Li Tan

Cai-Xia Pi

Mian Wan

Yi-Ran Peng

Ling Ye

Li-Wei Zheng

Xue-Dong Zhou

Affiliations

Soon will be listed here.

Abstract

Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear. In this study, we investigated the reassociation of tooth germ cells suspension from different morphological stages during tooth development and the phosphorylation of Smad2/3 in this process. Four tooth morphological stages were designed in this study. The results showed that tooth germ cells formed odontogenic tissue at embryonic day (E) 14.5, which is referred to as the cap stage, and they formed tooth-like structures at E16.5, which is referred to as the early bell stage, and E18.5, which is referred to as the late bell stage. Moreover, the transforming growth factor-β signalling pathway might play a role in this process.

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