Anti-Metastatic and Anti-Angiogenic Activities of Core-Shell SiO@LDH Loaded with Etoposide in Non-Small Cell Lung Cancer

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2016 Dec 17

PMID 27980999

Citations 11

Authors

Yanjing Zhu

Rongrong Zhu

Mei Wang

Bin Wu

Xiaolie He

Yechang Qian

Shilong Wang

Affiliations

Soon will be listed here.

Abstract

Currently, nanoparticles have gained a great attention in the anti-tumor research area. However, to date, studies on the anti-metastasis action of core-shell SiO@LDH (LDH: layered double hydroxide) nanoparticles remain untouched. Two emerging aspects considered are establishing research on the controlling delivery effect of SiO@LDH combined with anti-cancer medicine from a new perspective. The fine properties synthetic SiO@LDH-VP16 (VP16: etoposide) are practiced to exhibit the nanoparticle's suppression on migration and invasion of non-small cell lung cancer (NSCLC). Both in vitro and in vivo inspection shows that SiO@LDH can help VP16 better function as an anti-metastasis agent. On the other hand, anti-angiogenic efficiency, co-localization, as well as western blot are investigated to explain the possible mechanism. A clear mergence of SiO@LDH-VP16 and cytomembrane/microtubule may be observed from co-location images. Results offer evidence that SiO@LDH-VP16 plays positions on cytomembrane and microtubules. It efficiently inhibits metastasis on NSCLC by reducing vascularization, and eliciting depression of the PI3K-AKT and FAK-Paxillin signaling pathways. SiO@LDH-VP16, the overall particle morphology, and function on anti-metastasis and anti-angiogenic may be tuned to give new opportunities for novel strategies for cancer therapy.

Citing Articles

Composites formed by layered double hydroxides with inorganic compounds: An overview of the synthesis methods and characteristics.

Velazquez-Herrera F, Zarazua-Aguilar Y, Garzon-Perez A, Alvarez-Gomez K, Fetter G MethodsX. 2024; 13:102912.

PMID: 39280761 PMC: 11402166. DOI: 10.1016/j.mex.2024.102912.

The emergence of nanoporous materials in lung cancer therapy.

Radhakrishnan D, Mohanan S, Choi G, Choy J, Tiburcius S, Trinh H Sci Technol Adv Mater. 2022; 23(1):225-274.

PMID: 35875329 PMC: 9307116. DOI: 10.1080/14686996.2022.2052181.

Stable Cu Catalysts Supported by Two-dimensional SiO with Strong Metal-Support Interaction.

Wang S, Feng K, Zhang D, Yang D, Xiao M, Zhang C Adv Sci (Weinh). 2022; 9(9):e2104972.

PMID: 35075801 PMC: 8948561. DOI: 10.1002/advs.202104972.

Trifunctional Graphene Quantum Dot@LDH Integrated Nanoprobes for Visualization Therapy of Gastric Cancer.

Wu B, Li K, Sun F, Niu J, Zhu R, Qian Y Adv Healthc Mater. 2021; 10(16):e2100512.

PMID: 34110710 PMC: 11469055. DOI: 10.1002/adhm.202100512.

Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.

Ling X, Jiang X, Li Y, Han W, Rodriguez M, Xu Z ACS Nano. 2020; 15(1):765-780.

PMID: 33347262 PMC: 8216770. DOI: 10.1021/acsnano.0c07132.

References

Yu W, Chen L, Yang Y, Falck J, Guo A, Li Y . Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol. 2010; 68(3):619-29. PMC: 3839420. DOI: 10.1007/s00280-010-1521-8. View

Zhu R, Wang Q, Zhu Y, Wang Z, Zhang H, Wu B . pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on non-small cell lung cancer. Acta Biomater. 2015; 29:320-332. DOI: 10.1016/j.actbio.2015.10.029. View

Heinrich L, Freyria A, Melin M, Tourneur Y, Maksoud R, Bernengo J . Confocal laser scanning microscopy using dialkylcarbocyanine dyes for cell tracing in hard and soft biomaterials. J Biomed Mater Res B Appl Biomater. 2006; 81(1):153-61. DOI: 10.1002/jbm.b.30648. View

Pei S, Yang X, Wang H, Zhang H, Zhou B, Zhang D . Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2. BMC Cancer. 2015; 15:965. PMC: 4682252. DOI: 10.1186/s12885-015-1960-z. View

Patil R, Ljubimov A, Gangalum P, Ding H, Portilla-Arias J, Wagner S . MRI virtual biopsy and treatment of brain metastatic tumors with targeted nanobioconjugates: nanoclinic in the brain. ACS Nano. 2015; 9(5):5594-608. PMC: 4768903. DOI: 10.1021/acsnano.5b01872. View

Gritti F, Guiochon G . Comparison between the loading capacities of columns packed with partially and totally porous fine particles. What is the effective surface area available for adsorption?. J Chromatogr A. 2007; 1176(1-2):107-22. DOI: 10.1016/j.chroma.2007.10.076. View

Chambers A, MacDonald I, Schmidt E, Morris V, Groom A . Clinical targets for anti-metastasis therapy. Adv Cancer Res. 2000; 79:91-121. DOI: 10.1016/s0065-230x(00)79003-8. View

Hu H, Xiu K, Xu S, Yang W, Xu F . Functionalized layered double hydroxide nanoparticles conjugated with disulfide-linked polycation brushes for advanced gene delivery. Bioconjug Chem. 2013; 24(6):968-78. DOI: 10.1021/bc300683y. View

Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A . Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med. 2002; 346(2):85-91. DOI: 10.1056/NEJMoa003034. View

10.

Lai W, Wang W, Chang Y, Chang C, Yang P, Peck K . Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras. Biomaterials. 2014; 35(9):2905-14. DOI: 10.1016/j.biomaterials.2013.12.054. View

11.

Bartolome R, Garcia-Palmero I, Torres S, Lopez-Lucendo M, Balyasnikova I, Casal J . IL13 Receptor α2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis. Cancer Res. 2015; 75(12):2434-44. DOI: 10.1158/0008-5472.CAN-14-3650. View

12.

Agostinelli E, Tempera G, Viceconte N, Saccoccio S, Battaglia V, Grancara S . Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach. Amino Acids. 2009; 38(2):353-68. DOI: 10.1007/s00726-009-0431-8. View

13.

L Kiss A . Caveolae and the regulation of endocytosis. Adv Exp Med Biol. 2012; 729:14-28. DOI: 10.1007/978-1-4614-1222-9_2. View

14.

Bremnes R, Camps C, Sirera R . Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer. 2005; 51(2):143-58. DOI: 10.1016/j.lungcan.2005.09.005. View

15.

Chen C, Kim Yee L, Gong H, Zhang Y, Xu R . A facile synthesis of strong near infrared fluorescent layered double hydroxide nanovehicles with an anticancer drug for tumor optical imaging and therapy. Nanoscale. 2013; 5(10):4314-20. DOI: 10.1039/c3nr00781b. View

16.

Zaytseva Y, Rychahou P, Gulhati P, Elliott V, Mustain W, OConnor K . Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res. 2012; 72(6):1504-17. PMC: 3596828. DOI: 10.1158/0008-5472.CAN-11-4057. View

17.

Mammucari C, Schiaffino S, Sandri M . Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy. 2008; 4(4):524-6. DOI: 10.4161/auto.5905. View

18.

Lin Y, Liu A, Fan C, Zheng H, Li Y, Zhang C . MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1. Sci Rep. 2015; 5:9995. PMC: 4412117. DOI: 10.1038/srep09995. View

19.

Salvati A, Pitek A, Monopoli M, Prapainop K, Bombelli F, Hristov D . Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nat Nanotechnol. 2013; 8(2):137-43. DOI: 10.1038/nnano.2012.237. View

20.

Yuan X, Zhuo S, Xing W, Cui H, Dai X, Liu X . Aqueous dye adsorption on ordered mesoporous carbons. J Colloid Interface Sci. 2007; 310(1):83-9. DOI: 10.1016/j.jcis.2007.01.069. View