Novel Putative Receptor Tyrosine Kinase Encoded by the Melanoma-inducing Tu Locus in Xiphophorus

Overview

Journal Nature

Specialty Science

Date 1989 Oct 5

PMID 2797166

Citations 89

Authors

J Wittbrodt

D Adam

B Malitschek

W Maueler

F Raulf

A Telling

S M Robertson

M Schartl

Affiliations

Soon will be listed here.

Abstract

Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.

Citing Articles

Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation.

Soria E, Lu Q, Boswell W, Du K, Xing Y, Boswell M Pigment Cell Melanoma Res. 2024; 38(1):e13196.

PMID: 39289030 PMC: 11681846. DOI: 10.1111/pcmr.13196.

Phylogenomic analyses of all species of swordtail fishes (genus Xiphophorus) show that hybridization preceded speciation.

Du K, Ricci J, Lu Y, Garcia-Olazabal M, Walter R, Warren W Nat Commun. 2024; 15(1):6609.

PMID: 39098897 PMC: 11298535. DOI: 10.1038/s41467-024-50852-6.

Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?.

Frayer M, Payseur B Evolution. 2024; 78(6):1025-1038.

PMID: 38490748 PMC: 11135621. DOI: 10.1093/evolut/qpae044.

CD133-Dependent Activation of Phosphoinositide 3-Kinase /AKT/Mammalian Target of Rapamycin Signaling in Melanoma Progression and Drug Resistance.

Kharouf N, Flanagan T, Alamodi A, Al Hmada Y, Hassan S, Shalaby H Cells. 2024; 13(3.

PMID: 38334632 PMC: 10854812. DOI: 10.3390/cells13030240.

Validity of Xiphophorus fish as models for human disease.

Schartl M, Lu Y Dis Model Mech. 2024; 17(1).

PMID: 38299666 PMC: 10855230. DOI: 10.1242/dmm.050382.