Zika Virus Infection of Hofbauer Cells

Overview

Journal Am J Reprod Immunol

Specialties Allergy & Immunology
Reproductive Medicine

Date 2016 Dec 15

PMID 27966815

Citations 65

Authors

Michael K Simoni

Kellie Ann Jurado

Vikki M Abrahams

Erol Fikrig

Seth Guller

Affiliations

Soon will be listed here.

Abstract

Recent studies have linked antenatal infection with Zika virus (ZIKV) with major adverse fetal and neonatal outcomes, including microcephaly. There is a growing consensus for the existence of a congenital Zika syndrome (CZS). Previous studies have indicated that non-placental macrophages play a key role in the replication of dengue virus (DENV), a closely related flavivirus. As the placenta provides the conduit for vertical transmission of certain viruses, and placental Hofbauer cells (HBCs) are fetal-placental macrophages located adjacent to fetal capillaries, it is not surprising that several recent studies have examined infection of HBCs by ZIKV. In this review, we describe congenital abnormalities associated with ZIKV infection, the role of HBCs in the placental response to infection, and evidence for the susceptibility of HBCs to ZIKV infection. We conclude that HBCs may contribute to the spread of ZIKV in placenta and promote vertical transmission of ZIKV, ultimately compromising fetal and neonatal development and function. Current evidence strongly suggests that further studies are warranted to dissect the specific molecular mechanism through which ZIKV infects HBCs and its potential impact on the development of CZS.

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References

Sarno M, Sacramento G, Khouri R, do Rosario M, Costa F, Archanjo G . Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS Negl Trop Dis. 2016; 10(2):e0004517. PMC: 4767410. DOI: 10.1371/journal.pntd.0004517. View

Ingman K, Cookson V, Jones C, Aplin J . Characterisation of Hofbauer cells in first and second trimester placenta: incidence, phenotype, survival in vitro and motility. Placenta. 2010; 31(6):535-44. DOI: 10.1016/j.placenta.2010.03.003. View

Kyle J, Beatty P, Harris E . Dengue virus infects macrophages and dendritic cells in a mouse model of infection. J Infect Dis. 2007; 195(12):1808-17. DOI: 10.1086/518007. View

Romero R, Chaiworapongsa T, Espinoza J . Micronutrients and intrauterine infection, preterm birth and the fetal inflammatory response syndrome. J Nutr. 2003; 133(5 Suppl 2):1668S-1673S. DOI: 10.1093/jn/133.5.1668S. View

Joerink M, Rindsjo E, van Riel B, Alm J, Papadogiannakis N . Placental macrophage (Hofbauer cell) polarization is independent of maternal allergen-sensitization and presence of chorioamnionitis. Placenta. 2011; 32(5):380-5. DOI: 10.1016/j.placenta.2011.02.003. View

Balsitis S, Coloma J, Castro G, Alava A, Flores D, McKerrow J . Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg. 2009; 80(3):416-24. View

Chen K, Chen L, Lee Y . The role of preterm placental calcification in high-risk pregnancy as a predictor of poor uteroplacental blood flow and adverse pregnancy outcome. Ultrasound Med Biol. 2012; 38(6):1011-8. DOI: 10.1016/j.ultrasmedbio.2012.02.004. View

Kim J, Romero R, Kim M, Kim Y, Friel L, Espinoza J . Involvement of Hofbauer cells and maternal T cells in villitis of unknown aetiology. Histopathology. 2008; 52(4):457-64. PMC: 2896045. DOI: 10.1111/j.1365-2559.2008.02964.x. View

van der Eijk A, Genderen P, Verdijk R, Reusken C, Mogling R, van Kampen J . Miscarriage Associated with Zika Virus Infection. N Engl J Med. 2016; 375(10):1002-4. DOI: 10.1056/NEJMc1605898. View

10.

Calvet G, Aguiar R, Melo A, Sampaio S, de Filippis I, Fabri A . Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016; 16(6):653-660. DOI: 10.1016/S1473-3099(16)00095-5. View

11.

de Noronha L, Zanluca C, Azevedo M, Giovanni Luz K, Duarte Dos Santos C . Zika virus damages the human placental barrier and presents marked fetal neurotropism. Mem Inst Oswaldo Cruz. 2016; 111(5):287-93. PMC: 4878297. DOI: 10.1590/0074-02760160085. View

12.

Nelson D . Apoptotic changes occur in syncytiotrophoblast of human placental villi where fibrin type fibrinoid is deposited at discontinuities in the villous trophoblast. Placenta. 1996; 17(7):387-91. DOI: 10.1016/s0143-4004(96)90019-3. View

13.

Seval Y, Korgun E, Demir R . Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis. Placenta. 2007; 28(8-9):841-5. DOI: 10.1016/j.placenta.2007.01.010. View

14.

Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J . Zika Virus Associated with Microcephaly. N Engl J Med. 2016; 374(10):951-8. DOI: 10.1056/NEJMoa1600651. View

15.

Pacheco O, Beltran M, Nelson C, Valencia D, Tolosa N, Farr S . Zika Virus Disease in Colombia - Preliminary Report. N Engl J Med. 2016; 383(6):e44. DOI: 10.1056/NEJMoa1604037. View

16.

Mantovani A, Biswas S, Galdiero M, Sica A, Locati M . Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. 2012; 229(2):176-85. DOI: 10.1002/path.4133. View

17.

Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G . Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1. Am J Reprod Immunol. 2010; 65(5):470-9. PMC: 3071455. DOI: 10.1111/j.1600-0897.2010.00927.x. View

18.

Silasi M, Cardenas I, Kwon J, Racicot K, Aldo P, Mor G . Viral infections during pregnancy. Am J Reprod Immunol. 2015; 73(3):199-213. PMC: 4610031. DOI: 10.1111/aji.12355. View

19.

Redline R, Heller D, Keating S, Kingdom J . Placental diagnostic criteria and clinical correlation--a workshop report. Placenta. 2005; 26 Suppl A:S114-7. DOI: 10.1016/j.placenta.2005.02.009. View

20.

Jurado K, Simoni M, Tang Z, Uraki R, Hwang J, Householder S . Zika virus productively infects primary human placenta-specific macrophages. JCI Insight. 2016; 1(13). PMC: 5007065. DOI: 10.1172/jci.insight.88461. View