Brain-derived Neurotrophic Factor and Early-life Stress: Multifaceted Interplay

Overview

Journal J Biosci

Specialties Biochemistry
Biology

Date 2016 Dec 15

PMID 27966494

Citations 12

Authors

Natalya P Bondar

Tatiana I Merkulova

Affiliations

Soon will be listed here.

Abstract

The brain-derived neurotrophic factor (BDNF) is a key regulator of neural development and plasticity. Longterm changes in the BDNF pathway are associated with childhood adversity and adult depression symptoms. Initially, stress-induced decreases in the BDNF pathway were found in some studies, but subsequent reports indicated the relationship between stress and BDNF to be much more complex, and the concept was significantly revised. In the present mini-review, we focus on the structure and regulation of the Bbnf gene as well as on the stress-BDNF interactions under early-life adverse conditions.

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