Selective Serotonin Reuptake Inhibitor Sertraline Inhibits Voltage-dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells

Overview

Journal J Biosci

Specialties Biochemistry
Biology

Date 2016 Dec 15

PMID 27966486

Citations 5

Authors

Han Sol Kim

Hongliang Li

Hye Won Kim

Sung Eun Shin

Il-Whan Choi

Amy L Firth

Hyoweon Bang

Young Min Bae

Won Sun Park

Affiliations

Soon will be listed here.

Abstract

We examined the effects of the selective serotonin reuptake inhibitor (SSRI) sertraline on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. Sertraline decreased the Kv channel current in a dose-dependent manner, with an IC50 value of 0.18 mu M and a slope value (Hill coefficient) of 0.61. Although the application of 1 mu M sertraline did not affect the steady-state activation curves, sertraline caused a significant, negative shift in the inactivation curves. Pretreatment with another SSRI, paroxetine, had no significant effect on Kv currents and did not alter the inhibitory effects of sertraline on Kv currents. From these results, we concluded that sertraline dose-dependently inhibited Kv currents independently of serotonin reuptake inhibition by shifting inactivation curves to a more negative potential.

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