Magnetic Resonance Elastography and Diffusion Weighted Imaging in the Evaluation of Hepatic Fibrosis in Chronic Hepatitis B

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2016 Dec 15

PMID 27965475

Citations 18

Authors

Tiffany P Hennedige

Gang Wang

Fiona P Leung

Hind S Alsaif

Lynette Ls Teo

Seng Gee Lim

Aileen Wee

Sudhakar K Venkatesh

Affiliations

Soon will be listed here.

Abstract

Background/aims: Comparison of the accuracy of magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) for the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB).

Methods: In this retrospective analysis, we investigated 63 patients with CHB and liver fibrosis. DWI was performed with both breath-hold (DWI-BH) and free-breathing (DWI-FB) sequences (b=0, 500). The mean liver stiffness and apparent diffusion coefficient (ADC) were calculated by drawing regions of interest maps. Fibrosis staging according to the METAVIR system was independently performed by an experienced pathologist. A receiver operating curve (ROC) analysis was conducted to determine the accuracy of MRE, DWI-BH and DWI-FB in the detection and stratification of liver fibrosis. The performance of the detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was also evaluated by comparing areas under the ROC.

Results: There was a moderate and significantly negative correlation between the ADC values and liver stiffness. The accuracies for the detection of ≥F2/≥F3/F4 stage fibrosis with DWI-FB, DWI-BH and MRE were 0.84/0.76/0.72, 0.72/0.83/0.79 and 0.99/0.99/0.98, respectively. The performance of MRE was significantly better than DWI-FB and DWI-BH. There were no significant differences between the performance of DWI-FB and DWI-BH.

Conclusions: MRE is more accurate than DWI for the detection and stratification of liver fibrosis in CHB.

Citing Articles

Interpretation, Reporting, and Clinical Applications of Liver MR Elastography.

Moura Cunha G, Fan B, Navin P, Olivie D, Venkatesh S, Ehman R Radiology. 2024; 310(3):e231220.

PMID: 38470236 PMC: 10982829. DOI: 10.1148/radiol.231220.

Non-Invasive Assessment of Liver Fibrosis in Hepatitis B Patients.

Bera C, Hamdan-Perez N, Patel K J Clin Med. 2024; 13(4).

PMID: 38398358 PMC: 10889471. DOI: 10.3390/jcm13041046.

MR Elastography: Practical Questions, From the Special Series on Imaging of Fibrosis.

Yin M, Ehman R AJR Am J Roentgenol. 2023; 222(1):e2329437.

PMID: 37162036 PMC: 10636243. DOI: 10.2214/AJR.23.29437.

Diagnostic accuracy of magnetic resonance elastography and point-shear wave elastography for significant hepatic fibrosis screening: Systematic review and meta-analysis.

Schambeck J, Forte G, Goncalves L, Stuker G, Kotlinski J, Tramontin G PLoS One. 2023; 18(2):e0271572.

PMID: 36730265 PMC: 9894488. DOI: 10.1371/journal.pone.0271572.

Effect of breath holding at the end of the inspiration and expiration phases on liver stiffness measured by 2D-MR elastography.

Ren H, Yang D, Xu H, Pang K, Shi Y, Guan Q Abdom Radiol (NY). 2021; 46(6):2516-2526.

PMID: 33386913 DOI: 10.1007/s00261-020-02893-w.

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