Some Biochemical Markers in Patients with Alzheimer's Disease

Overview

Journal Iran J Public Health

Date 2016 Dec 14

PMID 27957443

Authors

Mohammad Khanahmadi

Dariush D Farhud

Maryam Malmir

Soheila Orang

Affiliations

Soon will be listed here.

Abstract

Background: Metal ions effect on homeostasis of Alzheimer's disease (AD) patients. The aim of this study was to assess the metal ions (Iron, Zinc and Copper) and CBC in patients with AD in comparison with normal range.

Methods: The samples of study were 17 patients with AD in Tehran's aging centers in 2015, selected as an access sample. Blood samples were analyzed in a pathobiology laboratory. Data were analyzed by one sample -test.

Results: According to the normal range, provided by laboratory, there is a significant difference between zinc in patients with AD and normal reference interval (α=0.01). The comparison of CBC of the AD patients with normal group showed also some decreases.

Conclusion: Zinc value in AD patients is significantly lower than normal range. It should be repeated by a larger sample size.

References

Ayton S, Lei P, Bush A . Metallostasis in Alzheimer's disease. Free Radic Biol Med. 2012; 62:76-89. DOI: 10.1016/j.freeradbiomed.2012.10.558. View

Bateman R, Munsell L, Morris J, Swarm R, Yarasheski K, Holtzman D . Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med. 2006; 12(7):856-61. PMC: 2983090. DOI: 10.1038/nm1438. View

Chow V, Mattson M, Wong P, Gleichmann M . An overview of APP processing enzymes and products. Neuromolecular Med. 2010; 12(1):1-12. PMC: 2889200. DOI: 10.1007/s12017-009-8104-z. View

Squitti R, Lupoi D, Pasqualetti P, Forno G, Vernieri F, Chiovenda P . Elevation of serum copper levels in Alzheimer's disease. Neurology. 2002; 59(8):1153-61. DOI: 10.1212/wnl.59.8.1153. View

Khanahmadi M, Farhud D, Malmir M . Genetic of Alzheimer's Disease: A Narrative Review Article. Iran J Public Health. 2015; 44(7):892-901. PMC: 4645760. View

Markesbery W . Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 1997; 23(1):134-47. DOI: 10.1016/s0891-5849(96)00629-6. View

Rembach A, Hare D, Doecke J, Burnham S, Volitakis I, Fowler C . Decreased serum zinc is an effect of ageing and not Alzheimer's disease. Metallomics. 2014; 6(7):1216-9. DOI: 10.1039/c4mt00060a. View

Bush A, Pettingell W, Multhaup G, Paradis M, Vonsattel J, Gusella J . Rapid induction of Alzheimer A beta amyloid formation by zinc. Science. 1994; 265(5177):1464-7. DOI: 10.1126/science.8073293. View

Vural H, Demirin H, Kara Y, Eren I, Delibas N . Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease. J Trace Elem Med Biol. 2010; 24(3):169-73. DOI: 10.1016/j.jtemb.2010.02.002. View

10.

Multhaup G, Bush A, Pollwein P, Masters C . Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP). FEBS Lett. 1994; 355(2):151-4. DOI: 10.1016/0014-5793(94)01176-1. View

11.

Bush A, Multhaup G, Moir R, Williamson T, Small D, Rumble B . A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. J Biol Chem. 1993; 268(22):16109-12. View

12.

Miyata M, Smith J . Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet. 1996; 14(1):55-61. DOI: 10.1038/ng0996-55. View

13.

Altamura S, Muckenthaler M . Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis. J Alzheimers Dis. 2009; 16(4):879-95. DOI: 10.3233/JAD-2009-1010. View

14.

Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K . Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011; 303(1-2):95-9. DOI: 10.1016/j.jns.2011.01.003. View

15.

Bush A, Pettingell Jr W, de Paradis M, Tanzi R, Wasco W . The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem. 1994; 269(43):26618-21. View

16.

Edwards D, Handsley M, Pennington C . The ADAM metalloproteinases. Mol Aspects Med. 2008; 29(5):258-89. PMC: 7112278. DOI: 10.1016/j.mam.2008.08.001. View

17.

Cui L, Schoene N, Zhu L, Fanzo J, Alshatwi A, Lei K . Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells. Am J Physiol Cell Physiol. 2002; 283(2):C623-30. DOI: 10.1152/ajpcell.00308.2001. View

18.

Xu H, Finkelstein D, Adlard P . Interactions of metals and Apolipoprotein E in Alzheimer's disease. Front Aging Neurosci. 2014; 6:121. PMC: 4054654. DOI: 10.3389/fnagi.2014.00121. View