Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

Overview

Journal Case Rep Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2016 Dec 14

PMID 27957352

Citations 3

Authors

Se Won Kim

Seung-Eun Lee

Young Lyun Oh

Seokhwi Kim

Sun Hee Park

Jae Hyeon Kim

Affiliations

Soon will be listed here.

Abstract

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

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An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production.

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[Metabolic disorders as paraneoplastic syndromes].

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